http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2534546-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb75b0b19820e3833ebdcb31603b242b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c13193fe65025a46525ac2b48f75f12a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-498 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2008-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b6afa06cb55f786bf8367ccbcb960bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36df9396169dec5f894038767592cfc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbfd2aeda402d139a13d7d332cbb0712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdac696c090d6bfda7f5fdbd77a61fba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c8c2bc14c2a16cd42dda71ec97ace7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae070f9e860d085b69610177eac2db9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91676d5c533c762dfae0930f748327ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53bd8b98bdb177496e44be3eee9cea0c |
| publicationDate | 2015-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2534546-T3 |
| titleOfInvention | Piperidine compounds, of the substituted quinoxaline type, and uses thereof |
| abstract | Compounds according to Formula (II): ** Formula ** or a pharmaceutically acceptable derivative thereof wherein: Y1 is O; Q is selected from heteroaryl (5 or 6 member) or fused benzo; each R2 is independently selected from: (a) -halo, -CN, -NO2, -OT3, -C (> = O) T3, -C (> = O) OT3, -C (> = O) N (T1 ) (T2), -S (> = O) 3H, -S (> = O) T3, -S (> = O) 2T3, - S (> = O) 2N (T1) (T2), -N ( T1) (T2), -N (T3) C (> = O) T3, -N (T3) C (> = O) N (T1) (T2), -N (T3) S (> = O) 2T3 , or -N (T3) S (> = O) 2N (T1) (T2); or (b) -C1-C6 alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, -C1-C6-alkoxy, -C3-C7-cycloalkyl, -C6-C14-cycloalkyl ), - tricycloalkyl (C8-C20), -cycloalkenyl (C5-C10), -bicycloalkenyl (C7-C14), -trichloralkenyl (C8-C20), -heterocycle (5 or 6 members), or -bicycloheterocycle (7 10 members), each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R8 groups; or (c) -phenyl, -naphthalenyl, -aryl (C14), or -heteroaryl (5 or 6 members), each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R7 groups; a is an integer selected from 0, 1 or 2; the dashed line in the 6-membered nitrogen-containing ring that is fused to group Q indicates the presence or absence of a bond, and when that dashed line indicates the presence of a bond, then R3 and R4 are absent ; R3 is selected from: (a) -H; or (b) -C1-C4 alkyl which is unsubstituted or substituted with 1, 2 or 3 groups independently selected from -OH, -C1-C4 alkoxy, -N (R6) 2, -C ( > = O) OR9, or -C (> = O) N (R6) 2; or (c) -C3-C7 -cycloalkyl which is not substituted or substituted with 1, 2 or 3 groups independently selected from -OH, -C1-C4 alkyl, -C1-C4 alkoxy, -N (R6) 2, -C (> = O) OR9, or -C (> = O) N (R6) 2; each R4 is independently selected from: (a) -H; or (b) -halo, -CN, or -NO2; or (c) -X, -C1-C6 alkyl-X, -heterocycle (5 or 6 members) -X, or -heterocycle (5 or 6 members) -C1-C6 alkyl -X; or (d) -C (> = Y) CN, -C (> = Y) X, -C (> = Y) T3, -C (> = Y) YX, -C (> = Y) YT3, - C (> = Y) N (T1) (T2), -C (> = Y) N (R9) CN, -C (> = Y) N (R9) X, - C (> = Y) N (R9 ) YH, -C (> = Y) N (R9) YX, -C (> = Y) N (R9) YCH2X, -C (> = Y) N (R9) YCH2CH2X, or -C (> = Y) N (R9) S (> = O) 2T3; or (e) -N (R9) X, -N (R9) -CH2X, -N (R9) -CH2CH2X, -N (R9) CH2N (R9) C (> = N (R12)) N (R12) 2 , -N (R9) - CH2CH2N (R9) C (> = N (R12)) N (R12) 2, -N (T1) (T2), -N (T3) C (> = Y) T3, -N (T3) C (> = Y) YT3, -N (T3) C (> = Y) N (T1) (T2), -N (T3) S (> = O) 2T3, or -N (T3) S (> = O) 2N (T1) (T2); or (f) -CH2YH, or -CH2CH2YH; or (g) -S (> = O) T3, -S (> = O) 2T3, -S (> = O) N (T1) (T2), -S (> = O) 2N (T1) (T2 ), -S (> = O) X, or -S (> = O) 2X; X is: (a) -H, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -C1-C6 alkoxy, -C3-C7 cycloalkyl, - bicycloalkyl (C6-C14), -tricycloalkyl (C8-C20), -cycloalkenyl (C5-C10), -bicycloalkenyl (C7-C14), -tricycloalkenyl (C8-C20), - heterocycle (5 or 6 members), or -bicycloheterocycle (7 to 10 members), each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R8 groups; or (b) -phenyl, -naphthalenyl, -aryl (C14), or -heteroaryl (5 or 6 members), each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R7 groups; each Y is independently selected from O or S; A and B are independently selected from: (a) -H, -CN, -C (> = O) OT3, or -C (> = O) N (T) 1 (T2); or (b) -C3-C12-cycloalkyl, -C3-C12-cycloalkoxy, -C1-C6-alkyl, -C2-C6-alkenyl, -C2-C6 -alkynyl, or -C1 -alkoxy C6), each of which is unsubstituted or substituted with 1 or 2 substituents independently selected from -OH, -S (> = O) 2NH2, -N (R6) 2,> = NR6, -C (> = O ) OT3, -CON (R6) 2, -N (R6) C (> = O) R9, and -heterocycle (5 or 6 members), or 1, 2 or 3 -halo independently selected; or (c) AB may together form a bridge (C2-C6), which is unsubstituted or substituted with 1, 2, 3, 4, 5, 6, 7 or 8 substituents independently selected from -OH, -C1 alkyl -C4), -halo, and -C (halo) 3, and optionally containing said bridge -HC> = CH- or -O- within the bridge (C2-C6); wherein the 6-membered nitrogen-containing ring that is fused to group Q may be in the endo- or exo- configuration with respect to the A-B bridge; or (d) A-B may together form a bridge -CH2-N (Ra) -CH2-, a ** Formula ** |
| priorityDate | 2007-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 96.