http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2534392-T3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9df2faf626ee27afc7732852a857d0fd |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-30 |
filingDate | 2007-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afb07c2e1d1bde4c3d93956810256733 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b0a817c560ed774a71857af201322da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c665dca2805a171ccd5ca122123e427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9eefc1b4be2d102ca3aec4310929976f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_610b123391ac9f653a3f2de673da6e31 |
publicationDate | 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2534392-T3 |
titleOfInvention | Human tyrosine phosphatase protein inhibitors and methods of use |
abstract | A compound of the formula: ** Formula ** in which R is a substituted or unsubstituted thiazolyl unit of the formula: ** Formula ** each of R2 and R3 is independently selected from: ** Formula ** i) hydrogen; ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted 5-membered or 6-membered heteroaryl ring, where at least one ring atom is a heteroatom selected from nitrogen, oxygen and sulfur; or R2 and R3 can be taken together to form a saturated or unsaturated ring having 5 to 7 atoms; R4 is a unit selected from: i) hydrogen; ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted 5-membered or 6-membered heteroaryl ring, where at least one ring atom is a heteroatom selected from nitrogen, oxygen and sulfur; said substitutions for R, R2, R3, and R4 are independently selected from one or more linear, branched or cyclic C1-C6 alkyl, -N (R16) 2, -OR16, halogen, or cyano units; each R16 is independently hydrogen, linear, branched or cyclic C1-C4 alkyl; Z is a unit of formula: R1 is selected from: i) hydrogen; ii) substituted or unsubstituted linear, branched or cyclic C1-C6 alkyl; iii) substituted or unsubstituted C6 aryl, where each substitution is independently selected from halogen, linear, branched or cyclic C1-C4 alkyl, -OR11, -CN, -N (R11) 2, -CO2R11, -C (O) N (R11) 2, -NR11C (O) R11, -NO2 and -SO2R11, each R11 is independently hydrogen, alkyl, alkenyl or C1-C4 linear, branched or cyclic substituted or unsubstituted alkynyl; substituted or unsubstituted phenyl or benzyl; or two R11 units can be taken together to form a ring comprising 3-7 atoms; iv) substituted or unsubstituted C1-C9 heterocyclic rings, where the heteroatoms are selected from nitrogen, oxygen and sulfur; or v) substituted or unsubstituted C1-C9 heteroaryl rings, where at least one atom in the ring is a heteroatom selected from nitrogen, oxygen or sulfur; L is a union unit selected from: i) -C (O) NH [C (R5aR5b)] w-; ii) -C (O) [C (R6aR6b)]) x-; iii) -C (O) [C (R7aR7b)] and C (O) -; iv) -SO2 [C (R8aR8b)] z-; each of R5a, R5b, R6a, R6b, R7a, R7b, R8a and R8b is independently: i) hydrogen; ii) substituted or unsubstituted linear or branched C1-C4 alkyl; iii) substituted or unsubstituted aryl; iv) substituted or unsubstituted heterocyclic rings; or v) substituted or unsubstituted C1-C9 heteroaryl; said substitutions for R1, R5a, R5b, R6a, R6b, R7a, R7b, R8a and R8b are independently selected from linear, branched or cyclic C1-C6 alkyl, phenyl and benzyl, C1-C9 heteroaryl, -C (O) R9 and -NHC (O) R9; R9 is linear or branched C1-C6 alkyl; linear or branched C1-C6 alkoxy; or -NHCH2C (O) R10; R10 is selected from hydrogen, methyl, ethyl and tert-butyl; the index n is 0 or 1; each of the indices w, x, y and z is independently from 1 to 4; or a pharmaceutically acceptable salt thereof. |
priorityDate | 2006-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 619.