http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2534335-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b755982699e3ea5199d569ee5f5344c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate | 2011-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c822dcc8dfae5d3f862a60e37c0ab1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b013f587971c9bc8e2cb1ad1ce3577ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54a681686f17c36661b3cb2bfc33ffae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_727818d3f037a5f4ff3a0f27c8e6ba51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e74c3c563bd9adc6fa7a5b7c85573093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b95bd7afa9ab68a9e88eab9211fab53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76ffa3b7afa820be3a34f25ea601918a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adf5175283850043cadc948e51f1d996 |
| publicationDate | 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2534335-T3 |
| titleOfInvention | Macrocyclic compounds as Trk kinase inhibitors |
| abstract | Compound of general formula I ** Formula ** or pharmaceutically acceptable salts thereof, in which: ring A is selected from rings A-1, A-2 and A-3 having the structures: ** Formula * * in which the wavy line marked 1 indicates the point of attachment of ring A to ring B and the wavy line marked 2 indicates the junction point of ring A to W; X is N or CH; Y is H or F; R1 is H, alkoxy (C1-3) or halogen; ring B is selected from rings B-1 and B-2 that have the structures: ** Formula ** in which the wavy line marked 3 indicates the point of attachment to ring A and the wavy line marked 4 indicates the point of attachment to the pyrazolo [1,5-a] pyrimidine ring of formula I; W is O, NH or CH2, where when ring A is A-2, then W is CH2; m is 0, 1 or 2; D is carbon, R2 and R2a are independently H, F, (C1-3) alkyl or OH (with the proviso that R2 and R2a are not both OH), and R3 and R3a are independently H, (C1-3) alkyl or hydroxyalkyl (C1-3), or D is carbon or nitrogen, R2 and R3 are absent, and R2a and R3a together with the atoms to which they are attached, form a 5-6 membered heteroaryl ring having 1-2 ring heteroatoms; Z is * -NR4aC (> = O) -, * -ONHC (> = O) -, * -NR4bCH2- or * -OC (> = O) -, in which the asterisk indicates the junction point of Z to carbon bearing R3; R4a is H, (C1-6) alkyl, fluoroalkyl (C1-6), difluoroalkyl (C1-6), trifluoroalkyl (C1-6), hydroxy (C1-6 alkyl) or dihydroxy (C2-6 alkyl); R4b is H, (C1-6) alkyl, fluoroalkyl (C1-6), difluoroalkyl (C1-6), trifluoroalkyl (C1-6), hydroxy (C1-6 alkyl), dihydroxy (C2-6 alkyl), (C1-6 alkyl) C (O) -, (C3-6 cycloalkyl) C (O) -, Ar1C (O) -, HOCH2C (O) -, (C1-6 alkyl) sulfonyl, (cycloalkyl of C3-6) sulfonyl, Ar2 (SO2) -, HO2CCH2- or (C1-6 alkyl) NH (CO) -; Ar1 is phenyl optionally substituted with one or more substituents independently selected from halogen, (C1-6) alkyl, and (C1-6) alkoxy; Ar2 is phenyl optionally substituted with one or more substituents independently selected from halogen, (C1-6) alkyl, and (C1-6) alkoxy; and R5 and R6 are independently H, halogen, OH, (C1-6) alkyl or hydroxyalkyl (C1-6). |
| priorityDate | 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 340.