http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2533356-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2786720cd363efcd84f5fd6492510e49 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2008-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9e5d937d83ff4d0f6c57dc35e9d0d17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae12b034eeb864f42b998750822af9cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ccfd10bfe1b692a9cd4ae87a9eb830e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a32463b4d1c50e5484af218b1ddc003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0b2b3e15f01761d75facd53ec5fa6ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0e420944b709cd065ad8f2558beb828 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4a3c0adf90f3fb7ae15c1f008b5580f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99c0262c97dfbe3c12852f27d8b36f25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03179f9275d82980acc290b0e8234b28 |
| publicationDate | 2015-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2533356-T3 |
| titleOfInvention | Triazole compounds that modulate the activity of Hsp90 |
| abstract | A compound represented by the following structural formula: ** Formula ** or a pharmaceutically acceptable salt thereof, in which: Y is O or S; R3 is -OH, -SH, -NR7H, -OR26, -SR26, -O (CH2) mOH, -O (CH2) mSH, -O (CH2) mNR7H, -S (CH2) mOH, -S (CH2) mSH, -S (CH2) mNR7H, -OC (O) NR10R11, -SC (O) NR10R11, -NR7C (O) NR10R11, -OC (O) R7, -SC (O) R7, -NR7C (O) R7 , -OC (O) OR7, -SC (O) OR7, -NR7C (O) OR7, -OCH2C (O) R7, -SCH2C (O) R7, -NR7CH2C (O) R7, -OCH2C (O) OR7, -SCH2C (O) OR7, -NR7CH2C (O) OR7, -OCH2C (O) NR10R11, -SCH2C (O) NR10R11, -NR7CH2C (O) NR10R11, -OS (O) pR7, -SS (O) pR7, - S (O) pOR7, -NR7S (O) pR7, -OS (O) pNR10R11, -SS (O) pNR10R11, -NR7S (O) pNR10R11, -OS (O) pOR7, -SS (O) pOR7, -NR7S (O) pOR7, -OC (S) R7, -SC (S) R7, -NR7C (S) R7, -OC (S) OR7, -SC (S) OR7, -NR7C (S) OR7, -OC ( S) NR10R11, -SC (S) NR10R11, -NR7C (S) NR10R11, -OC (NR8) R7, -SC (NR8) R7, -NR7C (NR8) R7, -OC (NR8) OR7, -SC (NR8 ) OR7, -NR7C (NR8) OR7, -OC (NR8) NR10R11, -SC (NR8) NR10R11, -NR7C (NR8) NR10R11, -OP (O) (OR7) 2 or -SP (O) (OR7) 2 ; R5 is -H, -X20R50, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an aralkyl optionally substituted or an optionally substituted heteroaralkyl; R7 and R8, in each case, are independently -H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, a optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; R10 and R11, in each case, are independently -H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, a heteroaryl optionally substituted, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl; or R10 and R11, taken together with the nitrogen atom to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl; R26 is a C1-C4 alkyl, R35 and R36, in each case, are independently -H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl , an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteroaralkyl, or R35 and R36, together with the N to which they are attached form a 5- to 7-membered heterocyclic ring; R50 is an optionally substituted aryl or an optionally substituted heteroaryl; X20 is a C1-C4 alkyl, NR7, C (O), C (S), C (NR8) or S (O) p; Z, in each case, is independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an aralkyl optionally substituted, an optionally substituted heteroaralkyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, alkoxy, haloalkoxy, -NR10R11, -OR7, -C (O) R7, -C (O) OR7, -C (S ) R7, -C (O) SR7, -C (S) SR7, -C (S) OR7, -C (S) NR10R11, -C (NR8) OR7, -C (NR8) R7, -C (NR8) NR10R11, -C (NR8) SR7, -OC (O) R7, -OC (O) OR7, -OC (S) OR7, -OC (NR8) OR7, -SC (O) R7, -SC (O) OR7 , -SC (NR8) OR7, -OC (S) R7, -SC (S) R7, -SC (S) OR7, -OC (O) NR10R11, -OC (S) NR10R11, -OC (NR8) NR10R11, -SC (O) NR10R11, -SC (NR8) NR10R11, -SC (S) NR10R11, -OC (NR8) R7, -SC (NR8) R7, -C (O) NR10R11, -NR8C (O) R7, - NR7C (S) R7, -NR7C (S) OR7, -NR7C (NR8) R7, -NR7C (O) OR7, -NR7C (NR8) OR7, -NR7C (O) NR10 R11, -NR7C (S) NR10R11, -NR7C (NR8) NR10R11, -SR7, -S (O) pR7, -OS (O) pR7, -OS (O) pOR7, -OS (O) pNR10R11, -S ( O) pOR7, -NR8S (O) pR7, -NR7S (O) pNR10R11, -NR7S (O) pOR7, S (O) pNR10R11, -SS (O) pR7, -SS (O) pOR7, -SS (O) pOR10R11, -OP (O) (OR7) 2 or -SP (O) (OR7) 2; t is 0, 1, 2, 3, or 4; p, in each case, is independently 1 or 2; m, in each case, is independently 1, 2, 3, or 4; wherein the optional substituents of the groups alkyl, alkylene, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, aralkyl, heteroaryl, and heteroaralkyl are selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heterocyclyl, aryl, heterocyclyl, aryl, heterocyclyl aralkyl, heteroaralkyl, haloalkyl, heteroalkyl, alkoxy, -C (O) NR28R29, -C (S) NR28R29, -C (NR32) NR28R29, -NR33C (O) R31, -NR33C (S) R31, -NR33C (NR32) R31, halo, -OR33, cyano, nitro, haloalkoxy, -C (O) R33, -C (S) R33, -C (NR32) R33, -NR28R29, -C (O) OR33, -C (S) OR33 , -C (NR32) OR33, -OC (O) R33, -OC (S) R33, -OC (NR32) R33, -NR30C (O) NR28R29, -NR33C (S) NR28R29, -NR33C (NR32) NR28R29, -OC (O) NR28R29, -OC (S) NR28R29, -OC (NR32) NR28R29, -NR33C (O) OR31, -NR33C (S) OR31, -NR33C (NR32) OR31, S (O) hR33, -OS (O) pR33, -NR33S (O) pR33, -S (O) p, NR28R29, -OS (O) p, NR28R29 or -NR33S (O) p, NR28R29 guanadino, -C (O) SR31, -C ( S) SR31, -C (NR32) SR31, -OC (O) OR31, -OC (S) OR31, -OC (NR32) OR31, -SC (O) R33, -SC (O) OR31, -SC (NR32 ) OR3), -SC (S) R33, -SC (S ) OR31, -SC (O) NR28R29, -SC (NR32) NR28R28, -SC (S) NR28R29, -SC (NR32) R33, -OS (O) for P31, -S (O) for P31, -NR30S (O) pOR31, -SS (O) pR33, -SS (O) pOR31, -SS (O) pNR28R29, -OP (O) (OR31) 2 or -SP (O) (OR31) 2; R28 and R29, in each case are independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl or heteroaralkyl; and R33 and R31, in each case, are independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl or heteroaralkyl; R32, in each case independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, -C (O) R33, -C (O) NR28R29, -S (O) pR33 or -S (O) pNR28R29; p 'is 0, 1 or 2; h is 0, 1 or 2; and in addition, alkyl, cycloalkyl, alkylene, a heterocyclyl, and any saturated part of an alkenyl, cycloalkenyl, alkynyl, aralkyl and heteroaralkyl group, may also be substituted with> = O,> = S,> = N-R32. |
| priorityDate | 2007-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 646.