http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2528948-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9880469dc8f12dad7c3ad95c6ab31fe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2010-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8cd03a7b3cae856962b11f4aa1abc5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc31294e0d9de4585d4f57ea6985ebe8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4775e043ee83eda7faad1a1ad14ccd55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27b0fa3abbba62dd4237103e9ec3e034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa20dfeaff3f6c9021f7af012d5425fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_872e8fa7cb43a6fd221f9b639464d7b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2896d5f231bdf276ee3907b1ada55da2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e76c9519e402a844e2e60ba1132b92b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5491db354270373db4fc6d9b19d77d00 |
| publicationDate | 2015-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2528948-T3 |
| titleOfInvention | Pyrrolidinone carboxamide derivatives as R-quemerin modulators (ChemR23) |
| abstract | A compound having the formula: or a stereoisomer, rotamer or an isotopically enriched variant thereof, wherein R1 is a member selected from the group consisting of hydroxyl, C1-8 alkyl, C2-8 alkenyl, C1-8 alkoxy , C 1-8 alkoxy-C 1-8 alkyl, C 1-8 haloalkyl, C 1-8 hydroxyalkyl, C 3-8 cycloalkyl, C 3-8 cycloheteroalkyl, C 3-8 cycloalkyl-C 1-3 alkyl, C 3-8 cycloheteroalkyl , heteroaryl, heteroaryl-C1-4 alkyl, aryloxyalkyl C1-4, aryl-C1-2 alkoxy-C1-4 alkyl, -NRaRb, and RaRbN-C1-4 alkyl where each of Ra and Rb is independently selected from the group consisting of H, C1-8 alkyl, C3-8 cycloalkyl, C1-8 haloalkyl, C3-8 cycloheteroalkyl, C1-8 alkoxy-C1-8 alkyl, mono- or di- (C1-4 alkyl) amino-C1 alkyl -4 and C1-8 hydroxyalkyl, or Ra and Rb combine with the nitrogen to which each is attached to form a 4- to 7-membered ring that optionally has an additional O or N as a ring member and is optionally substituted by 1 to 4 substituents selected from the group consisting of hydroxy, halogen, C 1-4 alkyl and C 1-4 haloalkyl; R2 is a member selected from the group consisting of H, C1-8 alkyl, C2-8 alkenyl; or optionally, R1 and R2 combine to form a four to six membered ring fused to the pyrrolidinone ring and having at least one ring vertex heteroatom selected from the group consisting of O, S and N; R3 and R3a are each members selected from the group consisting of H, halogen, C1-4 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C3-8 cycloheteroalkyl, C3-8 cycloalkyl-C1-3 alkyl and C3 cycloheteroalkyl -8-C1-3 alkyl; R 4 is a member selected from the group consisting of H, halogen, C 1-4 alkyl, C 2-6 alkenyl, C 1-4 hydroxyalkyl, C 1-4 alkoxy, C 1-4 alkoxy-C 1-4 alkyl, C 1-6 haloalkyl and mono- or di- (C1-4 alkyl) amino; R5 is a member selected from the group consisting of CF3, halogen, cyano, C1-4 alkyl, C2-6 alkenyl, C1-4 hydroxyalkyl, C1-5 alkoxy, C1-4 alkoxy-C1-4 alkyl, C1- alkoxy 4-C 1-4 alkoxy, C 3-8 cycloalkyl, C 3-8 cycloalkyloxy, C 3-8 cycloheteroalkyl, C 3-8 cycloheteroalkyl-C 1-3 alkyl and mono- or di- (C 1-4 alkyl) amino; R6 and R6a are each selected members the group consisting of hydrogen, halogen, cyano, C1-4 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C1-4 hydroxyalkyl, C1-5 alkoxy, C1-4 alkoxy C1-4, C1-4 alkoxy-C1-4 alkoxy, C3-8 cycloalkyl, C3-8 cycloalkyloxy, C3-8 cycloheteroalkyl, C3-8 cycloheteroalkyl C1-3 alkyl and mono- or di- (C1-4 alkyl) Not me; wherein any of the ring portions of R1, R2, R3, R3a, R4, R5, R6 and R6a, including the fused rings, are optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, alkyl C1-4, benzyl, oxo and C1-6 alkoxycarbonyl, and any of the cycloalkyl and cycloheteroalkyl portions optionally have a double bond between ring vertices; or a pharmaceutically acceptable salt thereof |
| priorityDate | 2009-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 750.