http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2528730-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f95845e28e2da5e04b10f4faae6e2cf8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2010-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0750da5c5e1c6d9a7ee25f73a6628571 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6988eb4fa2fb1ed55eae846d91f107a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b22b9e61c2aa3dd34b45b27f35c60a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cecc2317c706db2056e3f3c581f64e2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52f8a3584e6b1fe7071070ec83fa4d56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77b62d3f29d1d03e488f313cd2bedb0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15d8424314ae7c1f7df22450d27577ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c82a22ef02cabf31254ed71a691c64b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cce76a15c2c6e65a0c1200d71814dc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaacd0fe8a47210d58b4de2ac120ea8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d863f1257dbc1ff44cf4ca3d3ae96dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ad575edf178892ca6064785f2e725c |
| publicationDate | 2015-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2528730-T3 |
| titleOfInvention | 2-aminobenzoimidazol-5-carboxamides as anti-inflammatory agents |
| abstract | Compounds of general formula I ** Formula ** one of X and Y represents -N (R6) -; and the other represents -N> =; one of Z1, Z2 and Z3 represents, independently, -C (R7)> = or -N> =; and the other two of Z1, Z2 and Z3 represent - C (R7)> =; Q2, Q3 and Q4 represent, respectively, -C (R2)> =, -C (R3)> = and -C (R4)> =; or any one or two of Q2, Q3 or Q4 may represent, alternatively and independently, -N> =; R1 represents halo, OH, -CN; C1-3 alkyl, C2-6 alkynyl, O-C1-3 alkyl, these last three groups are optionally substituted with one or more substituents selected from fluorine, -CN,> = O, OH, -OCH3, - OCF3; R2, R3 and R4 independently represent hydrogen, halo, -CN; C1-3 alkyl, O-C1-3 alkyl, these last two groups are optionally substituted with one or more substituents selected from fluorine, -CN,> = O, OH, -OCH3, -OCF3; Ra, Rb independently represent hydrogen, C1-3 alkyl, or both together with the carbon atom to which they are attached, form a C3-7 cycloalkylene ring, or a 4-6 membered heterocycloalkylene ring; Rc represents hydrogen or C1-3 alkyl; W represents -C (O) -, -S (O) -, -S (O) 2-, -C (O) O- or -C (O) NRd-, groups that are attached to the nitrogen of the remainder -NRc20 by means of a carbon or sulfur atom; Rd represents hydrogen or C1-3 alkyl; M represents C1-7 alkyl, C3-7 cycloalkyl, both of said groups are optionally substituted with one or more groups selected from fluorine, -OH, -CN, -NH2, -NH (C1-3 alkyl), N (alkyl C1-3) 2, -O-C1-3 alkyl, -C1-3 alkyl, aryl, heteroaryl [these last two groups may be substituted with one or more substituents selected from halo, OH, -CN, C1-3 alkyl , O-C1-3 alkyl (these last two alkyl groups are optionally substituted with one or more fluorine atoms)], C1-7 alkyl, C2-7 alkynyl, C3-7 cycloalkyl-C0-2 alkyl, 4 - heterocycloalkyl 7-C0-2 alkyl members (the latter alkyl, alkynyl, heterocycloalkyl or cycloalkyl groups are optionally substituted with one or more substituents selected from fluorine, -CN,> = O, - NH2, -NH (C1-3 alkyl), -N (C1-3 alkyl) 2, -OH, -O-C1-3 alkyl); or 4-7-membered aryl, heteroaryl, heterocycloalkyl, groups which are all optionally substituted with one or more substituents selected from halo, -OH, -CN, -NH2, -NH (C1-3 alkyl), - N (C1-3alkyl) 2, -C1-3alkyl, -S-C1-3alkyl, aryl, heteroaryl [these last two groups may be substituted with one or more substituents selected from halo, OH, -CN, alkyl C1-3, -O-C1-3 alkyl (these last two alkyl groups are optionally substituted with one or more fluorine atoms)], C1-7 alkyl, C2-7 alkynyl, C3-7 cycloalkyl, 4-7 heterocycloalkyl members (the latter alkyl, alkynyl, heterocycloalkyl or cycloalkyl groups are optionally substituted with one or more substituents selected from fluorine, -CN,> = O, -NH2, -NH (C1-3 alkyl), N (C1-3 alkyl ) 2, -OH, -O-C 1-3 alkyl)]; R5 represents hydrogen; or C1-3 alkyl; R6 represents hydrogen; C1-5 alkyl, C3-6 alkynyl, 4-7 membered heterocycloalkyl-C0-2 alkyl or C3-7 cycloalkyl-C0-2 alkyl (these last four groups are optionally substituted with one or more substituents selected from fluorine, - CN,> = O, C1-3 alkyl, -OH, -O-C1-3 alkyl, -NH2, -NH (C1-3 alkyl), N (C1-3 alkyl) 2); each R7 independently represents hydrogen, halo, -CN, C1-7 alkyl, C2-7 alkynyl, C3-7 cycloalkyl, C1-5-O- alkyl, C3-7 cycloalkyl-C0-2-O- alkyl , 4-7 membered heterocycloalkyl-C0-2-O- alkyl, (in these last six groups the alkyl, alkynyl, cycloalkyl or heterocycloalkyl fragments are optionally substituted with one or more substituents selected from fluorine, -CN,> = O , OH, -O-C1-3alkyl, -NH2, -NH1-3alkyl, N (C1-3alkyl) 2 or with one or more C1-3alkyl groups, which may be optionally substituted with one or more atoms of fluorine); or aryl or heteroaryl, these last two groups may be substituted with one or more substituents selected from halo, OH, -CN, C1-3 alkyl, -O-C1-3 alkyl (in these last two groups the alkyl fragments are optionally substituted with one or more fluorine atoms); L represents -C (O) N (R8) -, -N (R8) C (O) -, -S (O) 2N (R8) -, - N (R8) S (O) 2-, - N ( R8) C (O) N (R8) -, -OC (O) N (R8) - or - N (R8) C (O) O-; A represents hydrogen, C1-8 alkyl, C3-8 alkynyl, aryl, heteroaryl, aryl-C1-3- alkyl, C3-8 cycloalkyl-C0-3- alkyl, 4-7 membered heterocycloalkyl-C0-3- alkyl, heteroaryl-C 1-3 alkyl-, groups in which the alkyl-, alkynyl-, cycloalkyl- and heterocycloalkyl- fragments are optionally substituted with one or more substituents selected from R9a and the aryl and heteroaryl fragments are optionally substituted with one or more substituents selected from R9b; or AL- together represent one of the following groups in which V represents a bond, -CH2CH2-, -CH2CH2CH2-, in which in each of these last alkylene groups a methylene unit [- (CH2) -] may optionally be replaced by an oxygen atom, a group -NH- or- N (C1-3 alkyl) - and each methylene unit may be optionally and independently substituted with one or two of the following groups: fluorine, -CN, > = O, -NH2, -NH (C1-3 alkyl), N (C1-3 alkyl) 2, -OH, -O-C1-3 alkyl); each R8 independently represents hydrogen, or C1-3 alkyl; each R9a independently represents fluorine, -OH, -CN,> = O, -NH2, -NH (C1-3 alkyl), -N (C1-3 alkyl) 2, -C1-6 alkyl, C1 alkyl -6, (in these last four groups the alkyl fragments are optionally substituted with one or more substituents selected from fluorine, -CN,> = O, -NH2, -NH (C1-3 alkyl), N (C1-3 alkyl ) 2, -OH, -C1-3alkyl) or aryl, heteroaryl [these last two groups may be substituted with one or more substituents selected from halo, OH, -CN, C1-3alkyl, O-C1-3alkyl (These last two alkyl groups are optionally substituted with one or more fluorine atoms)]; each R9b independently represents halo, -OH, -CN, -NH2, -NH (C1-3 alkyl), -N (C1-3 alkyl) 2, -O-C1-3 alkyl, -S-alkyl C1-3, aryl, heteroaryl [these last two groups may be substituted with one or more substituents selected from halo, OH, -CN, C1-3 alkyl, O-C1-3 alkyl (these last two alkyl groups are optionally substituted with one or more fluorine atoms)], C 1-7 alkyl, C 2-7 alkynyl, C 3-7 cycloalkyl, 4-7 membered heterocycloalkyl (the latter alkyl, alkynyl, heterocycloalkyl or cycloalkyl groups are optionally substituted with one or more substituents selected from fluorine, -CN,> = O, -NH2, -NH (C1-3 alkyl), N (C1-3 alkyl) 2, -OH, O-C1-3 alkyl); the salts thereof, in particular the physiologically acceptable salts thereof with organic or inorganic bases or acids. |
| priorityDate | 2009-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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