| abstract |
Peptide or pseudopeptide comprising a sequence of natural and / or unnatural amino acids, characterized in that it binds to the human receptor of low density lipoproteins (hLDLR) on the surface of cell membranes, and that it responds to the general formula (I ) next: (Xaa) jZ (Xaa) jMPR- (Xaa) kW (Xaa) l (I) where Xaa represents a natural amino acid or not and comprises an amino acid of configuration D, an uncoded amino acid or an amino acid containing a peptidomimetic bonding; Z and W represent two identical or different amino acids that allow the peptide to cycle; i, j, k and l are integers, identical or different, between 0 and 5; M indicates methionine or one of its isosters or one of its analogs, P indicates proline or one of its isosters or one of its analogs, R indicates arginine or one of its isosters or one of its analogs. |