http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2525488-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2008-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b22912639f430d00b2cbb055f99ca9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_378d505856a92efbb0226c2edec3214c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f20c7f51c8abfbf3e2cfbb83d452d727 |
| publicationDate | 2014-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2525488-T3 |
| titleOfInvention | Deletions in domain II of pseudomonas exotoxin A that reduce nonspecific toxicity |
| abstract | An isolated, mutated Pseudomonas (PE) exotoxin A comprising a sequence of the formula: R1n-FCS-R2n-R3n-PE functional domain III, wherein: n> = 0 or 1 independently for each of R1, R2 and R3; R1> = 1 to 10 amino acid residues; FCS> = a furin cleavage sequence of amino acid residues, the sequence is cleavable by furin and has an amino acid end and a carboxyl end, where the FCS: a) is represented by the formula P4-P3-P2-P1, wherein P4 is an amino acid residue at the amino end, P1 is an amino acid residue at the carboxyl end, P1 is an arginine or a lysine residue, and said sequence is cleavable at the carboxyl end of P1 by fury; b) (i) additionally comprises amino acid residues represented by P6-P5 at said amino end, (ii) additionally comprising amino acid residues represented by P1'-P2 'at said carboxyl end, (iii) wherein in addition P1 is an arginine or a lysine residue, P2 'is tryptophan, and P4 can be arginine, valine or lysine, as long as if P4 is not arginine, then P6 and P2 are basic residues, and (iv) said sequence is cleavable at the carboxyl end of P1 by furina; c) is selected from sec. with no. Ident .: 12-20; d) is sec. with no. of identification:, or a truncated version of it comprising RQPR (sec. with identification number: 21); or e) is sec. with no. ID: 11, or a truncated version of it comprising RSKR (sec. with ID number: 26); R2> = 1 to 10 amino acids; and R3> = 1 or more contiguous residues of residues 365-394 of sec. with no. of ident .: 1; functional domain III of PE is residues 395-613 of sec. with no. of Ident .: 1, which optionally comprises (i) substitutions in one or more residues corresponding to 609-613 of sec. with no. Ident .: 1, (ii) a substitution of glycine, alanine, valine, leucine, or isoleucine for arginine at a position corresponding to position 490 of sec. with no. Identification: 1, (iii) a substitution of alanine, glycine, serine or glutamine with one or more residues corresponding to the residues selected from D403, R412, R427, E431, R432, R458, D461, R467, R505, R513 , E522, R538, E548, R551, R576, K590, and L597 of sec. with no. of ident .: 1, where the waste of sec. with no. of ident .: 1 maintain immunogenicity of an epitope or subepittope of domain III of PE, or (iv) a combination of any of (i) - (iii), wherein the mutated PE does not include residues 1 to 273 and 285 to 364 of sec. with no. Ident .: 1. |
| priorityDate | 2007-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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