http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2524829-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2010-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bf69d77c7a94c6e71c6eb401e0590dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83feb63e7ed92d806a0910df564d60a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d56cfddb782818dba7e2053d85697ccd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c485608534eca5d67ed1bdec00c781fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f1e697155fc752ab353e3ceb4c96a0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cc1c1f495068d5d04f326d1e2de71bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8f8cd652891483e6fb74ecd3e0dcc64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_828e0064b188478b78ae5a23ce225dcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e901f1b46428540019f17638449a4343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_883b9e9cfde4994ad9983c1b95aa57ed |
| publicationDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2524829-T3 |
| titleOfInvention | New CCR2 receptor antagonists and uses thereof |
| abstract | Compounds according to formula (I), ** Formula ** in which R1 is a group selected from -H, -halogen, -CN, -O-C1-C4 alkyl, -C1-C4 alkyl, -CH> = CH2, -C≡CH, - CF3, -OCF3, -OCF2H and -OCFH2; wherein R7 is a ring selected from -C3-C8 cycloalkyl, -C3-C8 heterocyclyl, -C5-C10 -aryl and -C5-C10 heteroaryl, where ring R7 is optionally substituted with one or more groups selected from -CF3, -O-CF3, -S-CF3, - CN, - C1-C6 alkyl, -C (CH3) 2-CN and -halogen, or where the R7 ring is optionally substituted with one or more groups selected from -C1 alkyl- C6, -O-C1-C6-alkyl, -C5-C10 -aryl, -C5-C10-heteroaryl, -C3-C8 -cycloalkyl, -C3-C8-heterocyclyl, -C2-C6 -alkenyl and -C2-C6 -alkyl, optionally substituted by one or more groups selected from -OH, -NH2, -C1-C3 alkyl, -O-C1-C6 alkyl, -CN, -CF3, -OCF3, halogen, -methyl and> = O, or where the R7 ring is additionally optionally substituted bi-valent in two adjacent atoms in the ring, such that an anelated ring is formed with one or more groups selected from -C1-C6 alkylene, -C2-C6 alkenylene and -C4-C6 alkenylene in which one, two or three centers d and carbon may optionally be replaced by 1, 2 or 3 heteroatoms selected from N, O and S, the bivalent group being optionally substituted with one or more groups selected from -OH, -NH2, -C1-C3 alkyl, -O-C1-alkyl -C6, -CN, -CF3, -OCF3, halogen and> = O; where R2 is selected from -H, -halogen, -CN, -O-C2-C4 alkyl, -C1-C4 alkyl, -CH> = CH2, -C≡CH, -CF3, -OCF3, - OCF2H and -OCFH2 ; wherein R3 is selected from -H, -methyl, -ethyl, -propyl, -i-propyl, -cyclopropyl, -OCH3, -CF3 and -CN; in which n is 1, 2 or 3; wherein G and E are independently selected from C-H or N; In which Z is C, and R4 and R5 are independently selected from -H, -C1-C6 alkyl, -NH2, -C3-C8 cycloalkyl, -C3-C8 heterocyclyl, -C5-C10 aryl, -C5 heteroaryl- C10 and -C (O) -N (R8, R8 '), R8 and R8' being independently selected from -H and -C1-C6 alkyl, or where Z is N, and R4 represents a pair of electrons and R5 is selected from -H, -C1-C6 alkyl, -NH2, -C3-C8 cycloalkyl, - C3-C8 heterocyclyl, -C5-C10 aryl, -C5-C10 heteroaryl and -C (O) -N (R8, R8 '), where R8 and R8' are independently selected from -H and -C1-C6 alkyl, and in which R4 and R5, if they are different from an electron pair or are -H, they are optionally independently substituted with one or more groups selected from -halogen, -OH, -CF3, -CN, -C1-C6 alkyl, -O-C1-C6 alkyl, -O-C3-C8 cycloalkyl, -O-C3-C8 heterocyclyl, -O-C5- aryl C10, -O-heteroaryl C5-C10, -alkylene C0-C6-CN, -alkylene C0-C4-O-C1-C4 alkyl, -alkylene C0-C4-O-cycloalkyl C3-C8, -alkylene C0-C4- C3-C8 O-heterocyclyl, -C0-C4-O-aryl C5-C10, -C0-C4-O-heteroaryl C5-C10, -C0-C4-Q-alkyl-C0-C4-N (R9, R9 '), -C0 alkylene -C4- N (R10) -Q-C1-C4 alkyl, -C0-C4-N-alkyl (R10) -Q-C3-C8 cycloalkyl, -C0-C4-N (R10) -Q-C3-C8 heterocyclyl , -C0-C4-N (R10) -Q-C5-C10-aryl, -C0-C4-N (R10) -Q-C5-C10-heteroaryl, -C0-C4-QN-alkylene (R11, R11 ') , -C0-C4-N (R12) -QN (R13, R13 '), -C0-C4-R14, -C0-C4- (R20, R20'), -C0-C4-Q-alkyl C1-C6, -C0-C4-Q-C3-C8-alkyl-alkyl, -C0-C4-Q-C3-C8-heterocyclyl, -C0-C4-Q-aryl-C5-C10-alkylene, -C0-C4-Q-alkylene -C5-C10 heteroaryl, -C0-C4-OQN (R15, R15 ') and -C0-C4-N (R16) -QO- (R17), where Q is selected from -C (O) - and - SO2-, where R10, R12, R16, are independently selected from -H, -C1-C6 alkyl and -C3-C6 cycloalkyl, where R9, R9 ', R11, R11', R13, R13 ', R15, R15', are independently selected from -H, -C1-C6 alkyl and -C3-C6 cycloalkyl, or where R9 and R9 ', R11 and R11' , R13 and R13 ', R15 and R15' together form a group -C2-C6 alkylene, where R14 and R17 are independently selected from -H, -C1-C6 alkyl, -C5-C10 aryl, -C5-C10 heteroaryl, - C3-C8 cycloalkyl and -C3-C8 heterocyclyl, wherein said C3-C8 heterocyclyl optionally comprises nitrogen and / or -SO2- in the ring. |
| priorityDate | 2009-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1525.