http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2524787-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12c55bccd1fd65bcfc98462f94922ecc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 |
| filingDate | 2008-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_121772833530631ea7b655a0dcadd467 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f91a435198327389d0bc882307a99a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_210481435a62674be4bb83ee30b85354 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d4fa245063cbae1a06f40b2fec9445f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6296d773f0f8ab50118677fced268cd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_690528ae10fa6f68ffffc9940f55e638 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9332ada43f2e2dda5b2cb83f01466733 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c4ec926df43ed9884753ae5b0bf743c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07f822fd2ca5c145e7979090908c7122 |
| publicationDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2524787-T3 |
| titleOfInvention | Pyridazinone derivatives as PARP inhibitors |
| abstract | A compound of formula structure I: ** Formula ** in which: a is 0 or 1; b is 0 or 1; c is 0, 1, 2, 3 or 4; d is 1 or 2; e is 0, 1, 2, 3 or 4; f is 0, 1, 2, 3 or 4; A is a 6 to 15-membered monocyclic, condensed, bridged or spiro saturated heterocyclic ring containing two N and zero atoms or an O atom, substituted with an oxo group; each R1 is independently C1-6 alkyl, C1-6 haloalkyl, halogen or cyano; each R2 is independently hydroxy, halogen, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy or NRaRb; each of R3 and R4 is independently hydrogen, halogen, C1-6 alkyl or C1-6 haloalkyl; each R5 is independently cyano, halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C2-10 alkenyl, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl or a ring which is: C3-10 cycloalkyl, C6-10 aryl, C6-10 aryloxy, oxetanyl, azetidinyl, a saturated or partially saturated 5 or 6 membered heterocyclic ring containing 1, 2 or 3 atoms independently selected from N, O and S, a ring 5-membered heteroaromatic containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S, not more than one heteroatom of which is O or S, a 6-membered heteroaromatic ring containing 1, 2 or 3 atoms of N or an unsaturated, partially saturated or saturated 7-10 membered heterocyclic ring containing 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; any of whose rings is optionally substituted with one, two or three groups independently selected from R6; each R6 is independently hydroxy, oxo, cyano, halogen, nitro, C1-6 alkyl, C1-6 alkoxy, C2-10 alkenyl, C1-6 haloalkyl, C1-6 haloalkoxy, -O (C> = O) C1- alkyl 6, - (C> = O) C1-6alkyl, NRaRb, CONRaRb, NRaCORb, S (O) rNRaRb, S (O) rRc, NRaS (O) rRc or a ring which is: C3-10 cycloalkyl, C6 aryl -10, C6-10 aryl-C 1-6 alkyl, C6-10 arylcarbonyl, C6-10 aryloxycarbonyl, C6-10 arylC 1-6 alkoxycarbonyl, a 5-membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms selected independently between N, O and S, no more than one heteroatom of which is O or S or a 6-membered heteroaromatic ring containing 1, 2 or 3 nitrogen atoms; any of whose rings is optionally substituted with one, two or three groups independently selected from halogen, C1-6 alkyl or C1-6 haloalkyl; r is 0, 1 or 2. |
| priorityDate | 2007-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1686.