http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2524577-T3

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filingDate 2011-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_394e8b93704815c08b8dce51624976dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43664f7743bdc553812493117748e5f1
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publicationDate 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2524577-T3
titleOfInvention Process for the preparation of contrast agents
abstract A process for the preparation of a 5 - [(2-hydroxyacyl) amino] -2,4,6-triiodine derivative of the general formula (5) or a pharmaceutically acceptable salt thereof: ** Formula ** in which : R is, independently at each occurrence, a group selected from: -COOR 'and -CON (R') 2; R 'is, independently at each occurrence: hydrogen or a linear or branched (C1-C4) alkyl group, optionally substituted by one or more hydroxy group (s), as such (s) or in a protected form thereof; and X is hydrogen or a linear or branched (C1-C4) alkyl group; by Smiles transposition of a compound of the general formula (4) or of a salt thereof: ** Formula ** in which: R, R 'and X are defined as described above; said transposition obtained by bringing the compound (4) into contact with a solid anion exchange phase, in the presence of an aqueous solvent.
priorityDate 2010-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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