| abstract |
Compounds of formula (I) ** Formula ** in which: m, n are independently zero or an integer from 1 to 4; P is zero or an integer from 1 to 3; R is hydrogen; C1-C6 alkyl, optionally substituted by C3-C8 cycloalkyl, C6-C10 aryl or hetero-aryl (C2-C9); (CO) R2; C3-C8 cycloalkyl; C6-C10 aryl or hetero-aryl (C2-C9); R1 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy or C1-C6 haloalkoxy; Y is CH2 or NR4; Z is C> = R5; R2 is C1-Ce alkyl; C6-C10 aryl; O-C1-C6-alkyl; R4 is hydrogen; C1-C6 alkyl, optionally substituted by C6-C10 aryl or by hetero-aryl (C2-C9); R5 is oxygen or NOR8; R8 is hydrogen; C1-C6 alkyl, optionally substituted by C6-C10 aryl; and wherein one or more of said C6-C10 aryl and (C2-C9) heteroaryl groups is optionally substituted with one or more substituents selected from halogen, hydroxyl, NH2, CN, C1-C6 alkyl, C1- haloalkyl. C6, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6-alkyl, C1-C6-dialkyl amino or phenyl, and the pharmaceutically acceptable salts thereof; with the proviso that when p is zero, then n and m cannot both be 1. |