| abstract |
A diphenyl sulfide derivative, or a salt acceptable for pharmaceutical or hydrate use thereof, represented by the general formula (1), ** Formula ** in which in the formula (1), R 1 represents a hydrogen atom, a halogen atom, a trifluoromethyl group, an optionally substituted alkyl group having 1 to 6 carbon atoms, an optionally substituted cycloalkyl group having 3 to 6 carbon atoms, an optionally substituted aryl group having 6 to 10 carbon atoms , an optionally substituted alkoxy group having 1 to 4 carbon atoms, an optionally substituted benzyloxy group, an optionally substituted acyl group having 1 to 4 carbon atoms, a cyano group, or a carboxyl group; R2 represents an optionally substituted alkyl group having 1 to 6 carbon atoms or an optionally substituted alkenyl group having 2 to 6 carbon atoms; X represents a methylene group that can be substituted with 1 or 2 fluorine atoms or represents an oxygen atom; Y represents a hydrogen atom or an optionally substituted alkyl group having 1 to 6 carbon atoms; and Z represents a halogen atom; and wherein the optional substituents of the "alkyl group having 1 to 6 carbon atoms," the "cycloalkyl group having 3 to 6 carbon atoms, the" aryl group having 6 to 10 carbon atoms, "the" alkoxy group having 1 to 4 carbon atoms, "the" benzyloxy group, the "acyl group having 1 to 4 carbon atoms," and the "alkenyl group having 2 to 6 carbon atoms" each is independently selected from the group consisting of a halogen atom, a trifluoromethyl group, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an aryl group having 6 to 10 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a benzyloxy group, an acyl group having 1 to 4 carbon atoms, a cyano group, an alkenyl group having 2 to 6 carbon atoms, a hydroxyl group, a group nitro, and an amino group. |