http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2513391-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48bca8eb08e3f3f86eb72998b251361a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1841 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1858 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 |
| filingDate | 2009-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a2d1d8429ac07498d0688c8330c759e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1101e02dd33a53d55eca7391d0ff4319 |
| publicationDate | 2014-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2513391-T3 |
| titleOfInvention | Production procedure of a coagulable concentrate of platelet growth factors |
| abstract | A method of preparing a coagulable virally inactivated platelet growth factor concentrate containing both fibrinogen and factor XIII, comprising the following steps: a) contacting a non-activated starting platelet concentrate with a solvent and / or a detergent, wherein said solvent is preferably selected from the group consisting of di- or trialkyl phosphates, di- or trialkyl phosphates with different alkyl chains, and is preferably tri-n-butyl phosphate (TnBP), in which said detergent is preferably selected from the group consisting of polyoxyethylene fatty acid derivatives, partial esters of sorbitol anhydrides, non-ionic detergents, sodium deoxycholate and sulfobetaines, and is more preferably Triton® x-45, Triton® X-100 or Tween ® 80, and in which the final concentration of each of said solvent and / or said detergent preferably ranges from 0.2 to 5 % by volume with respect to the volume of the starting platelet concentrate; b) incubating said starting platelet concentrate with the solvent and / or detergent for a period of at least 5 minutes to 6 hours, at a pH maintained in a range of about 6.0 to about 9.0, and at a temperature within in the range of 2 ° C to 50 ° C, and c) remove the solvent and / or detergent by extraction with oil and / or chromatographic media, in which the oil extraction is preferably carried out with a pharmaceutical grade oil, the oil being used in an amount of 2 to 20% by weight, or 5 to 15% by weight or 5 to 10% by weight, based on the weight of the mixture of the platelet concentrate with the solvent and / or the detergent, and in wherein the chromatographic means preferably comprise a hydrophobic column (reverse phase), preferably a C18 silica packing material or an SDR (solvent-detergent removal) Hyper D, or an adsorption chromatographic column such as a chromatographic column anionic and / or cationic; said method comprising another step of inactivating viruses not involved by nanofiltration. |
| priorityDate | 2008-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.