| abstract |
A compound of Formula Ia: ** Formula ** or a tautomer, simple stereoisomer, racemate, mixture of enantiomers and diastereomers, or geometric isomer thereof and optionally as a salt acceptable for pharmaceutical or solvate use thereof; where W1, W2, W3, and W4 are -C (R1)> =; or one or two of W1, W2, W3, and W4 are independently -N> = and the rest are -C (R1)> =; and where each R1 is independently hydrogen, alkyl, haloalkyl, nitro, alkoxy, haloalkoxy, halo, hydroxy, cyano, amino, alkylamino, or dialkylamino; R51 is methyl; R50, R52, and R53 are hydrogen and R54 is halo or alkoxy; or R50, R52, and R54 are hydrogen and R53 is alkoxy; R3 is not present or R3 is methyl, methoxy or halo; and R3a is -N (R7) C (O) -C1-C6-N alkylene (R7a) (R7b) where R7 is hydrogen and R7a and R7b are independently hydrogen, alkyl, aminoalkyl, alkylaminoalkyl, or dialkylaminoalkyl. |