| abstract |
An antibody or an antigen-binding fragment that has specificity towards at least one antigen, wherein the at least one antigen is FcRIIIA and where the binding molecule does not specifically bind to FcRIIIB, where the antibody or fragment that antigen binding comprises six CDRs, wherein the amino acid sequence of CDR1 of the heavy chain is SEQ ID NO: 17, the amino acid sequence of CDR2 of the heavy chain is SEQ ID NO: 18, the amino acid sequence of CDR3 of the heavy chain is SEQ ID NO: 19, the CDR1 amino acid sequence of the light chain is selected from the group consisting of SEQ ID NOs: 20, 23, 26, 29, 33 and 34, the amino acid sequence of light chain CDR2 is selected from the group consisting of SEQ ID NOs: 21, 24, 27, 30, 31 and 35; and the light chain CDR3 amino acid sequence is selected from the group consisting of SEQ ID NOs: 22, 25, 28 and 32 |