http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2505324-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6923d7e117939c572e849772e2fc2e9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca32fd2a44fd326ffd027a75a57bd13f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8eaf3a66651a1e243e201863785b5d4d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y406-01001 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 |
| filingDate | 2009-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d0824cd94aa324ae9871a91ce4b6fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d00dc7f49f49f8e1265e6da4f5d58a03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d01398069d3ad60acb5952eaa0a6f53d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_959e993bc76769c3b20245adc5d58038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7afb683c118d4abbc5d9f10e8ba4119c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57ab215be98bbc923861038d87c69b53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cf7a0777be636d320a0f94264137962 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ddf231389f19da11885317d293e2e41 |
| publicationDate | 2014-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2505324-T3 |
| titleOfInvention | Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules to a cell |
| abstract | A polypeptide whose amino acid sequence comprises or consists of one of the following sequences: (a) an amino acid sequence that is a fragment that has a stretch of amino acids 5 comprising amino acid residues 1 to 860 or 2 to 860 of SEQ ID No. 1, in which: (i) the rest of glutamic acid, corresponding to position 570 in the sequence of the native CyaA of Bordetella pertussis defined in SEQ ID No. 1, is substituted by a glutamine residue; and (ii) the lysine residue, corresponding to position 860 in the Bordetella pertussis native CyaA sequence defined in SEQ ID No. 1, is substituted by an arginine residue, said fragment having the ability of Bordetella CyaA protein pertussis of binding to the CD11b / CD18 receptor of cells expressing it, the ability to translocate their N-terminal adenylate cyclase enzyme domain into said cells and having a pore-forming activity that is reduced or suppressed compared to that of the native CyaA toxin; or, b) an amino acid sequence that differs from a fragment that has a stretch of amino acids comprising amino acid residues 1 to 860 or 2 to 860 of SEQ ID No. 1, by: (i) the substitution of the rest of glutamic acid , corresponding to position 570 in the native CyaA sequence of Bordetella pertussis defined in SEQ ID NO: 1, by a glutamine residue; (ii) the substitution of the lysine residue, corresponding to position 860 in the native CyaA sequence of Bordetella pertussis defined in SEQ ID NO: 1, by an arginine residue; and (iii) 1 to 50 additional substitutions; the polypeptide consisting in said sequence having the ability of Bordetella pertussis CyaA protein to bind to the CD11b / CD18 receptor of cells expressing it, the ability to translocate its N-terminal adenylate cyclase enzyme domain into said cells and having a pore-forming activity that is reduced or suppressed compared to that of the native CyaA toxin. |
| priorityDate | 2009-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 475.