abstract |
Guanidine compound of general formula I corresponding enantiomeric, diastereomeric and / or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof, where the indicated moieties have the following definitions: where A: is halogen, OH, CN, CF3, CHF2, OCF3 , OCHF2, or C1-C6 alkyl or C2-C6 alkenyl, -O-CH2-COO-RA 1, O-RA 1, S-RA 1, NRA 2RA 3, -NRA 4-CO-RA 1, SO2NH2, NRA 4-SO2-RA 1, SO2-NRA 2RA -CO-NRA 4-RA 1 in each case eventually replaced; RA 1: C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, (C1-C4) alkylene-C3-C7 cycloalkyl, (C1-C4) alkylene-heterocycloalkyl, aryl, heteroaryl, heterocycloalkyl, alkylene (C1-C4) -aryl, alkenylene (C2-C6) -aryl or alkylene (C1-C6) -hetaryl in each case optionally substituted; RA 2: hydrogen, OH, CN, or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C1-C4) alkylene-C3-C7 cycloalkyl, (C1-C4) alkylene-heterocycloalkyl, aryl, heteroaryl, heterocycloalkyl, (C1-C4) alkylene, alkyl (C1-C4) -hetaryl, alkylene (C1-C6) -O-C1-C6 alkyl, CO-C1-C6 alkyl, CO-aryl, CO-heteroaryl, CO-alkylene (C1-C4) -aryl, CO-(C1-C4) -heteroyl, CO-O-C1-C6-alkyl, COO-aryl, CO-O-alkylene (C1-C4) -aryl, CO-O-heteroaryl , CO-O-(C1-C4) -hetaryl, SO2-C1-C6-alkyl, SO2-aryl, SO2-heteroaryl, SO2-alkylene (C1-C4) -aryl or SO2-alkylene (C1-C4) -hetaryl in each case eventually replaced; RA 3: C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (C1-C4) alkylene-C3-C7 cycloalkyl, (C1-C4) -heterocycloalkyl, aryl, heteroaryl, heterocycloalkyl, (C1-C4) alkylene ) -aryl, (C1-C4) alkylene -hetaryl, (C1-C6) alkylene -O-C1-C6 alkyl, CO-C1-C6 alkyl, CO-aryl, CO-hetaryl, CO-(C1-C4) alkylene , CO-C1-C4 alkylene -hetaryl, CO-O-C1-C6 alkyl, COO-aryl, CO-O-alkylene (C1-C4) -aryl, CO-O-heteroaryl, CO-O-alkylene ( C1-C4) -hetaryl, SO2-C1-C6 alkyl, SO2-aryl, SO2-heteroaryl, SO2-alkylene (C1-C4) -aryl or SO2-alkylene (C1-C4) -hetaryl in each case optionally substituted; or the residues RA 2 and RA 3 together with the nitrogen form a saturated or aromatic heterocycle, optionally substituted, of 3 to 7 members which may contain one, two or three additional heteroatoms different or equal from the group O, N, S; where eventually two substituted moieties in this heterocycle may together form a condensed, saturated, unsaturated or aromatic carbocycle or heterocycle, where the heterocycle may contain up to three different or equal heteroatoms O, N, S, and where the cycle formed due to it may be optionally substituted or in this cycle another possibly substituted cycle may be condensed; RA 4: hydrogen, or C1-C6 alkyl, (C1-C6) alkylene-O-C1-C6 alkyl, C2-C6 alkenyl, C3-C12 alkynyl, CO-C1-C6 alkyl, CO-O-C1-C6 alkyl , SO2-C1-C6 alkyl, C3-C7 cycloalkyl, aryl, alkylene (C1-C4) -aryl, CO-O-arylalkyl, CO-alkylene (C1-C4) -aryl, COaryl, SO2-aryl, heteroaryl, CO -hetaryl or SO2-(C1-C4) alkylene -aryl in each case optionally substituted; B: hydrogen or is defined as the remainder A, RW 1: hydrogen, F, Cl, CN, CF3, CHF2, O-CF3, OCHF2, C1-C4 alkyl, O-C1-C4 alkyl, aryl, (C1-) alkyl C6) -amino or dialkyl (C1-C6) -amino optionally substituted; Q: it is a substituted 5-membered hetaryl moiety, selected from |