| abstract |
A hormonal or antihormonal steroid compound of structure II, in which R1 is (R2R3N) -, in which R2 and R3 may be combinations of H, C1-C4 alkyl, C3-C6 cycloalkyl, C2-C4 alkenyl or C2- alkynyl C4, any of which may be optionally substituted; or R1 is (R2R3 (O)) -, in which R2 and R3 may be combinations of C1-C4 alkyl, C3-C6 cycloalkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of which may be optionally substituted; or where R1 is ** Formula ** in which q is 0 or 1, Y is - (CH2) m-, where m is an integer from 0 to 5, or Y is - (CH2) nZ- ( CH2) p-, where n> = 0 to 2, p> = 0 to 2 and Z is a heteroatom, optionally substituted and where CH2 groups may be optionally substituted; or R1 is (N-imidazolyl) - or (N-pyrrolyl) -; or R1 is halo-, HO-, CF3SO2O-, CH3O-, CH3S-, CH3S (O) -, CH3S (O2) -, CH3CO-, CH3CH (OH) -, NC-, HCC-, C6H5CC-, (2 '- or 3'-furyl), (2'- or 3'-thiophenyl) -, (2', 3'- or 4'-pyridyl) -, (2'-thiazolyl) -, (2'-N- methylimidazolyl) -, (5'-pyrimidinyl) -, C6H5-, H2C> = CH-, C2H5-, or MeC (> = CH2) -; and R12 is H or halo; or R1 and R12 combine to form a ring ** Formula ** |