http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2487967-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 |
| filingDate | 2007-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f59a5364b9c5d5c499a8e0cb6ba5a53c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9036841c5d12e6aba59eb690c3f2a485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a858e032520024ab489dda0f8b389aae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3c404c2f1464652422f21b4bd21bcd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_481baaa913842340c27677bee15f1d7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b925a28808a288227c5f5792e780bd8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a556c3e4c4c5c421db78f2c68473352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_333b4c5cb75236b27221cac43d075ffb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6d6f3f3fad335bd7f4f851a879bbe9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33a45ba70c5494e983d91b56225b59a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80d5dd42453d7824bbf3a44962211bd9 |
| publicationDate | 2014-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2487967-T3 |
| titleOfInvention | Heterocyclic amido compounds condensed with phenyl for the prevention and treatment of glucokinase mediated diseases |
| abstract | A compound of formula (VIa): ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein: ring A is pyrazinyl; L1 is -O-, -NR5, or -S-; R1, R1a, and R4 are independently selected from H, halo, cyano, nitro, -CF3, -CHF2, -CH2F, trifluoromethoxy, azido, hydroxy, (C1-C6) alkoxy, (C1-C6) alkyl, (C2) alkenyl -C6), (C2-C6) alkynyl, - (C> = O) -R5, - (C> = O) -O-R5, -O- (C> = O) -R5, -NR5 (C> = O) -R7, - (C> = O) -NR5R6, -NR5R6, -NR5OR6, -S (O) kNR5R6, -S (O) jalkyl (C1-C6), -O-SO2-R5, -NR5 -S (O) k, - (CR5R6) vcycloalkyl of (3-10) members, - (CR5R6) varyl (C6-C10), - (CR5R6) vheterocyclyl of (4-10) members, - (CR5R6) q ( C> = O) (CR5R6) varilo (C6-C10, - (CR5R6) q (C> = O) (CR5R610) vheterocyclyl of (4-10) members, - (CR5R6) vO (CR5R6) qaryl (C6-C10 ), - (CR5R6) vO (CR5R6) qheterocyclyl of (4-10) members, - (CR5R6) qS (O) j (CR5R6) varilo (C6-C10), and - (CR5R6) qS (O) j (CR5R6 ) vheterocyclyl of (4-10) members; or R1 and R4, if both are attached to a carbon atom of the C-ring, together optionally form a cycloalkyl ring of (3-10) members or a heterocyclyl of (4-10) members; L2 is> C> = O,> C> = OO-, -OC> = O-, -OC> = OO-, -OC> = O-NR5-, -NR5- (C> = O) - , -NR5- (C> = O ) -O-, -NR5- (C> = O) -NR615, - (C> = O) -NR5-, -O-, -NR5, -S (O) j-, -NR5SO2-, -SO2NR5- , - (C> = O) NR5SO2-, -SO2NR5 (C> = O) -, or -CR5R6; R2 is H, (C1-C6) alkyl, - (CR5R6) vcycloalkyl of (3-10) members, - (CR5R6) varyl (C6-C10), or - (CR5R6) vheterocyclyl of (4-12) members; R2 is H, (C1-C6) alkyl, - (CR5R6) vCycloalkyl of (3-10) members, - (CR5R6) varyl (C6-C10), - (CR5R6) vheterocyclyl of (4-12) members, R3 is H, halo, cyano, nitro, -CF3, -CHF2, -CH2F, trifluoromethoxy, azido, hydroxy, (C1-C6) alkoxy, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl , - (C> = O) -R5, - (C> = O) -O-R5, -O- (C> = O) -R5, -NR5 (C> = O) -R7, - (C> = O) -NR5R6, -NR5R6, -NR5OR6, -S (O) kNR5R6, -S (O) jalkyl (C1-C6), -O-SO2-R5, -NR5-S (O) k, - (CR5R6 ) vCycloalkyl of (3-10) members, - (CR5R6) varyl (C6-C10), - (CR5R6) v heterocyclyl of (4-10) members, - (CR5R6) q (C> = O) (CR5R6) varilo (C6-C10), - (CR5R6) q (C> = O) (CR5R6) vheterocyclyl of (4-10) members, - (CR5R6) vO (CR5R6) qaryl (C6-C10), - (CR5R6) vO ( CR5R6) qheterocyclyl of (4-10) members, - (CR5R6) qS (O) j (CR5R6) varilo (C6-C10), or - (CR5R6) qS (O) j (CR5R6) vheterocyclyl of (4-10) members; R5, R6 and R7 are each independently selected from H, (C1-C6) alkyl, - (CR8R9) (3-10) member cycloalkyl, - (CR8R9) paryl (C6-C10), and - (CR8R930) pheterocyclyl of (4-10) members; any carbon atom of alkyl (CrC6), cycloalkyl of (3-10) members, aryl (C6-C10) and heterocyclyl of (4-10) members of R1, R2, R3, R4, R5, R6 and R7 above are optionally and independently substituted with 1 to 3 R11 substituents each independently selected from halo, cyano, nitro, -CF3, -CHF2, -CH2F, trifluoromethoxy, azido, hydroxy, -O-R12 alkoxy (C1-C6 ), (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, - (C> = O) -R8, - (C> = O) -R12, - (C> = O) -O-R8, - (C> = O) -O-R12, -O- (C> = O) -R8, -O- (C> = O) -R1235, -NR8 (C> = O) - R10, - (C> = O) -NR8R9, - (C> = O) -NR8R12, -NR8R9, -NR8R12, -NR8OR9, -NR8OR12, -S (O) kNR8R9, -S (O) kNR8R12, -S (O) jalkyl (C1-C6), -S (O) jR12, -O-SO2-R8, -O-SO2-R12, -NR8-S (O) k, -NR12-S (O) k, - (CR8R9) vcycloalkyl of (3-10) members, - (CR8R9) varyl (C6-C10), - (CR8R9) vheterocyclyl of (4-10) members, - (CR8R9) q (C> = O) (CR8R9) varyl (C6-C10), - (CR8R9) q (C> = O) (CR8R9) vheterocyclyl of (4-10) members, - (CR8R9) vO (CR8R940) qaryl (C6-C10), - (CR8R9) vO (CR8R9) (4-10) member heterocyclyl, - (CR8R9) q (O) j (CR8R9) varyl (C6-C10), and - (CR8R9) qS (O) j (CR8R9) vheterocyclyl of (4-10) members; any carbon atom of the alkyl (CrC6), the cycloalkyl of (3-10) members, the aryl (C6-C10) and the heterocyclyl of (4-10) members of the above R11 are optionally and independently substituted with 1 to 3 R13 substituents each independently selected from halo, cyano, nitro, -CF3, -CHF2, -CH2F, trifluoromethoxy, azido, (CH2) vOH, (C1-C6) alkoxy, (C1-C6) alkyl, (C2) alkenyl -C6), (C2-C6) alkynyl, - (C> = O) -R8, - (C> = O) -R12, - (C> = O) -O-R8, - (C> = O) -O- R12, -O- (C> = O) -R8, -O- (C> = O) -R12, -NR8 (C> = O) -R10, - (C> = O) -NR8R9, -NR8R9, and -NR8R12; Any heterocyclyl nitrogen atom of (4-10) members of R1, R2, R3, R4, R5, R6, R7, R11 and R12 above are each optionally and independently substituted with (C1-C6) alkyl, (C2) alkenyl -C6), (C2-C6) alkynyl, - (C> = O) -R8, - (C> = O) -O-R8, - (C> = O) -NR8R9, - (CR8R9) vcycloalkyl of ( 3-10) members, - (CR8R9) varilo (C6-C10), - (CR8R9) vheterocyclyl of (4-10) members, - (CR8R9) q (C> = O) (CR8R9) varilo (C6-C10, or - (CR8R9) q (C> = O) (CR8R9) vheterocyclyl of (4-10) members, each R8, R9 and R10 are independently, H or (C1-C6) alkyl. |
| priorityDate | 2006-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1688.