http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2485891-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c509c10f7993bf4185abf29e4bf8d50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 |
| filingDate | 2011-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c935d0233bdb3102a4b7a8946e61fd95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b712a54395739739b2f1969982c9e9de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40a0f18408a82477bd3f61815a1a8b7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3a2a45661dc8b935fcd95c2cd3335c9 |
| publicationDate | 2014-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2485891-T3 |
| titleOfInvention | Synthesis of substituted pyrazoline carboxamidine derivatives |
| abstract | A process for the preparation of a compound of the Formula (I): or a tautomer, stereoisomer, or a pharmaceutically acceptable salt of any of the foregoing, wherein: - R1 is selected from hydrogen or an (C1-4) alkyl group , optionally substituted with one to three fluorine atoms or a hydroxy group, - R2 represents hydrogen or a (C1-4) alkyl group, optionally substituted with one to three fluorine atoms, a hydroxy group, a benzyloxymethyl group, an amino group , a monomethyl amino group, a dimethylamino group or a Boc-, Fmoc- or Cbz-protected amino group, whose (C1-4) alkyl group may incorporate a keto group, a sulfonyl group or an N, O or S atom, - R3 represents hydrogen or a (C1-4) alkyl group, optionally substituted with one to three fluorine atoms, a hydroxy group, a benzyloxymethyl group, an amino group, a monomethyl amino group, a dimethylamino group or a Boc- amino group , Fmoc- or Cbz-protected, whose (C1-4) alkyl group can incorporate a group c eto, a sulfonyl group or an atom of N, O or S, or R1 and R2, together with the carbon atoms labeled 'a' and 'b' form a C5-8-cycloalkyl ring, optionally substituted with one to three atoms of fluorine, a hydroxy group or a (C1-4) alkyl group, or, R2 and R3, together with the carbon atom labeled 'b' form a C3-8-cycloalkyl ring, optionally substituted with one to four fluorine atoms , one or two methyl groups or a hydroxy group, or R2 and R3, together with the carbon atom labeled 'b' form a C5-8-heterocycloalkyl ring optionally substituted with one to four fluorine atoms, one or two methyl groups, a benzyl group or a hydroxy group, - R4 represents hydrogen or a (C1-4) alkyl group, optionally substituted with one to three fluorine atoms or a hydroxy group, or R4 represents a monocyclic aryl or heteroaryl group optionally substituted with one to five Q substituents that may be the same or different, selected from halogen, trifluoromethyl, trifluoromethoxy, cia no, C1-3-alkyl, C1-3-alkoxy, hydroxy, amino, acetyl, acetamido, trifluoroacetamido, -CONH2, -SO2NH2 or -CO2H, or R3 and R4, together with the carbon atoms labeled 'b' and ' c 'form a C3-8-cycloalkyl ring, optionally substituted with one to four fluorine atoms, one or two methyl groups or a hydroxy group, or R3 and R4, together with the carbon atoms labeled' b 'and' c ' they form a C5-8-heterocycloalkyl ring optionally substituted with one to four fluorine atoms, one or two methyl groups, a benzyl group or a hydroxy group, - R5 represents hydrogen or methyl, - R6 is selected from hydrogen atom, or a (C1-4) alkyl group, optionally substituted with one to three fluorine atoms or a hydroxy group, - R7 represents a monocyclic group, or a fused bicyclic hetero-aromatic or aromatic group, whose groups are unsubstituted or substituted with one to five Q substituents, as defined above or R7 represents a 2-aryl-ethenyl group or a 2-aryl-ethynyl group, or R7 represents a piperidinyl group unsubstituted or substituted with one to four fluorine atoms or a CF3 group, or R7 represents a 2,3-dihydroindoleyl group or a benzimidazol-2-one group. |
| priorityDate | 2010-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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