http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2483993-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1224e3c07b7cc5684ee81d9e1e5ee15c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-46 |
| filingDate | 2009-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bd1f5ba60eda75f67fa357113855b54 |
| publicationDate | 2014-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2483993-T3 |
| titleOfInvention | Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol |
| abstract | Process for dimerization of 5-acetamido-N, N'-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-isophthalamide (Compound A) where the temperature during dimerization is in the range of 10 to 20 ° C, which uses a solvent mixture comprising 70 to 90% by volume of 1-methoxy-2-propanol and 10 to 30% by volume of water or methanol in a concentration of 0.8 to 2.0 ml of solvent per gram of Compound A in the presence of 0.30 to 0.40 mole equivalents of epichlorohydrin with respect to Compound A, wherein the reaction solution has a pH of 11.0 to 12.5 and where the pH is varied to throughout the entire dimerization having a higher value at the beginning of the dimerization than at the end thereof. |
| priorityDate | 2009-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.