http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2480994-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-429 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 2009-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a505b7b0a9a2e80e8d0a40d583efb182 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfef3f9c066a685088a1a0fe6d550c34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e1cff5bfe32286ddedb585186707635 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7f1761786f48d869b2bd9dc14ee1b37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57c521c9af1f1eaf1e4076e58b576d10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d944a13a1a340455f9cb058cc357e506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83e00e04bf89d508402d496c3afda472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a068f7959e6f778ddf18ac1b9c3885c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cd786a7e47f1931e8cdec52eaf9eec3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c3fbbb48e348f2ee759f5f302da864c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_342e7d536c42140cfc9e863baf9b5ac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7343de85fb86db5bf012ac4accdb57c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_575256341c50bfed651be5bf1899b3a6 |
| publicationDate | 2014-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2480994-T3 |
| titleOfInvention | Compounds of benzopyran and benzoxepine PI3K inhibitors and methods of use |
| abstract | A compound selected from Formula I: and stereoisomers, geometric isomers, tautomers or pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; where (i) X1 is N and X2 is S, (ii) X1 is S and X2 is N, (iii) X1 is CR7 and X2 is S or (iv) X1 is S and X2 is, CR7; R1, R2, R3 and R4 are independently selected from H, F, Cl, Br, I, -CN, -CF3, -CH2OR10, -CH2R10, - (C1-C12 alkylene) NR10R11, - (C1-C12 alkylene) NR12C (> = O) R10, - (C1-C12 alkylene) C (> = O) OR10, - (C1-C12 alkylene) OR10, -CO2R10, -C (> = O) N (R10) OR11, -NO2, -NR10R11, -OR10 5 -S (O) 2R10, -C (> = O) NR10R11, -C (> = O) NR10 (C1-C12 alkylene) NR10R11, -C (> = O) NR10 (C1-alkylene C12) NR10C (> = O) OR11, -C (> = O) NR10 (C1-C12 alkylene) NR10C (> = O) R11, -C (> = O) NR10 (C1-C12 alkylene) R10, -C (> = O) NR10) NR10R11 5 -NR12C (> = O) R10, -NR12C (> = O) OR11 5 -NR12C (> = O) NR10R11, -NR12C (> = O) (C1-C12 alkylene) NR10R11 , -NR12 (C1-C12 alkylene) NR10R11, -NR12 (C1-C12 alkylene) OR10, -NR12 (C1-C12 alkylene) C (> = O) NR10R11, -C-CR10, -CH> = CHR10, C2 heterocyclyl -C20, C1-C20 heteroaryl and phenyl, wherein the heterocyclyl, heteroaryl, phenyl and alkylene are optionally substituted with one or more groups selected from F, Cl, Br, I, -CH2OH5 - (CH2) 2OH, -CH2CO2H, -CN , -CH2NH2, - (CH2) 2N (CH3) 2, -CH3, -C (O) CH3, -C (O) NHCH3, -CO2H, -CH2CO2CH3, -N H2, -OCH3, -S (O) 2CH3, 4-methylpiperazin-1-yl and 4-morpholinyl; A is selected from -C (O) NR5R6, C2-C20 heterocyclyl and C1-C20 heteroaryl where C2-C20 heterocyclyl and C2-C20 heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I , -CH2OH, -CH2CO2H, -CH (CH3) CH2OCH3, -CN, C1-C12 alkyl, - (C1-C12 alkylene) NR10R11, - (C1-C12 alkylene) OR10, -CH3, -C (> = O) CH3, -C (> = O) NHCH3, -C (> = O) N (CH3) 2, -CO2H, -CO2CH3, -CH2CO2CH3, -NH2, -NHC (O) CH3, -OCH3, -S (O ) 2CH3, 1-methylpiperid-4-yl, 4-methylpiperazin-1-yl, 4-morpholinyl, isopropyl, isobutyl, cyclopropyl, cyclopropylmethyl, cyclobutyl, triazolylmethyl, benzyl and phenyl, where alkyl, alkylene, benzyl and phenyl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CF3, -CH2OH, -CH2CO2H, -CN, -CH2NH2, -CH3, -C (O) CH3, -C (> = O) NHCH3, -CO2H, -CH2CO2CH3, -NH2, -OH, -OCH3, -S (O) 2CH3, 1-methylpiperid-4-yl, (4-methylpiperazin-1-yl) carboxamide, -CH2 (1H-1, 2,4-triazol-5-yl), 4-methylpiperazin-1 -yl and 4-morpholinyl; R5 is selected from C1-C12 alkyl optionally substituted with one or more groups independently selected from F, Cl, Br, I, -CN, -CO2H, -CONH2, -CONHCH3, -NH2, -NO2, -N (CH3) 2 , -NHCOCH3, -NHS (O) 2CH3, -OH, -OCH3, -OCH2CH3, -S (O) 2NH2 and -S (O) 2CH3; R6 is selected from C1-C12 alkyl, C3-C12 carbocyclyl, C2-C20 heterocyclyl, C1-C20 heteroaryl and C6-C20 aryl, each optionally substituted with one or more groups independently selected from F, Cl, Br, I, - CH2OH, -CH2C6H5, -CN, -CF3, -CO2H, -C (O) NR10R11, -NH2, -NO2, -N (CH3) 2, -NHCOCH3, -NHS (O) 2CH3, -OH, -OCH3, -OCH2CH3, -S (O) 2NH2, -S (O) 2CH3, -C (> = O) NR10 (C1-C12 alkylene) NR10R11, morpholin-4-yl, piperidin-1-yl, piperazinyl, piperazin-4 -il-2-one, piperazin-4-yl-3-one, pyrrolidin-1-yl, thiomorpholin-4-yl, S-dioxothiomorph Iin-4-yl, -C-CR13, -CH> = CHR13 and -C (O) NR10R11; or R5 and R6 together with the nitrogen atom to which they are attached form morpholin-4-yl, piperidin-1-yl, piperazinyl, piperazin-4-yl-2-one, piperazin-4-yl-3-one, pyrrolidine -1-yl, thiomorpholin-4-yl or S-dioxothiomorpholin-4-yl, each optionally substituted with one or more groups selected from F, Cl, Br, I, -CH2OH, -CH2C6H5, -CN, -CF3, -CO2H, -CONH2, -CONHCH3, -NO2, -N (CH3) 2, -NHCOCH3, -NHS (O) 2CH3, -OH, -OCH3, -OCH2CH3, -S (O) 2NH2 and -S (O) 2CH3; R7 is selected between H and F. |
| priorityDate | 2008-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 2516.