http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-247953-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1959-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_227f28748d3c9dc0aaf711eeb7e8d3f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0343727124a2d7de4dda97cd1ee3acb5 |
| publicationDate | 1959-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-247953-A1 |
| titleOfInvention | A METHOD FOR THE MANUFACTURE OF QUINOLEINE COMPOUNDS |
| abstract | A method for the manufacture of quinoline compounds of the formula (I) and their addition salts ** (See formula) ** in which formula R1 and R2 are the same or different and represent hydroxy or alkoxy groups, each of which has from one to four carbon atoms and R2 may also represent a hydrogen atom, R3 is a hydrogen atom or an alkyl group having two to four carbon atoms and carrying a hydroxy group on at least one of the carbon atoms other than the one adjacent to the piperazine ring, and X being a normal or branched aliphatic hydrocarbon chain, having three to seven atoms of carbon, provided that, when R1 is a methoxy group and R2 and R3 are both hydrogen atoms, X must be other than an unbranched hexamethylene group, comprising: (1) the preparation of compounds having R1 or R2 as a hydroxy group by the acid hydrolysis of the corresponding alkoxy compounds; and (2) the preparation of compounds having R1 as an alkoxy group and R2 as hydrogen atoms or an alkoxy group, by condensation reactions between: (a) an 8-aminoquinoline and an alkylating agent derived from an N-alkyl-N '-R3-piperazine or an N-alkyl-N'-alkoxycarbonylpiperazine, or (b) an N-R3-piperazine or an N-alkoxycarbonylpiperazine and an alkylating agent derived from an 8-alkylamino quinoline, or (c) an 8- piperazine-alkylaminoquinoline and an alkylating agent derived from a hydroxyalkyl group, followed by removal by alkaline hydrolysis of the alkoxycarbonyl group, if present; and, if desired, (3) the release of the free base of the formula (I) from the reaction medium and, if desired, (4) the transformation of the free base of the formula (I) into a salt of acid addition. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1958-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.