http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2477270-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_924e7c147fb3152f6e8677ea3d8454c9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2010-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f71fba7f42869e8ffca8fb25dd532cf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25bd18e1c8a8c4c8d673e53fcc20a286 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_428dd0dcc75983335a2009fa94f7eaa2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a10cb8eaa4731a91b0c7d9408ba0d28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c0ccf8432b2d488ea7866afc2f3baa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d2081f30a5d73b40dcc41f7d811152f |
| publicationDate | 2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2477270-T3 |
| titleOfInvention | Quinazolin-4 (3H) -one derivatives used as PI3 kinase inhibitors |
| abstract | A compound of formula (I) in which R1 is H, a saturated or unsaturated, branched or unbranched C1-15 alkyl chain, in which one or more carbons are optionally substituted or substituted by a heteroatom selected from O, N, S (O) p, wherein said chain is optionally substituted with one or more groups independently selected from oxo, halogen, an aryl group, a heteroaryl group, a carbocyclyl group or a heterocyclyl group, each aryl, heteroaryl, carbocyclyl group having or heterocyclyl: 0 to 3 substituents selected from halogen, -hydroxy, -C1-6 alkyl, -C1-6 alkoxy, -C2-3 -alkoxy-C1-3 alkyl, -C2-3-O-alkyl C1-3, -C1-3 hydroxyalkyl, -C1-6 haloalkyl, amino, -mono-C1-4alkyl- or -C2-8 -alkyl-alkyl, -mono-C1-4 acyl- or -C2 alkyl -8-amino, -C0-6-S (O) p-C1-6 alkyl, -C0-6-S-alkyl (O) pNR6R7, -C0-6-NR8-C0-6S alkyl (O) C1-6 alkyl, -C0-6-C (O) alkyl C0-6 alkyl, -NR8C0-6-C (O) alkyl NR6 R7, -NR8 C0-6-C (O) C0-6 alkyl, -C0-6-C alkyl (O) NR6R7, and -C0-6-C (O) C1-6 alkyl; and / or an aryl, heterocyclyl or carbocyclyl; X is C6-10 aryl or C5-9 heteroaryl, each substituted with R2a and with R2b, in which R2a is selected from hydrogen, -C1-3alkyl, halo, hydroxyl, cyano, -C1 -haloalkyl 3, -C1-3alkoxy, -C2-3-O-C1-3alkyl, -C2-3-O -C1-3alkyl, -C1-3 hydroxyalkyl, -C0-6alkyl S (O) C1-3alkyl, -C0-6- S alkyl (O) pNR6R7, -C0-6-NR8 alkyl C0-6-S (O) C1-6 alkyl, -C0-6-C alkyl (O) OH, -C0-6-C alkyl (O) O-C1-6 alkyl, -NR8C0-6-C alkyl (O) NR6R7, -NR8-C0-6-C alkyl (O) C1 alkyl -6, -C0-6-C (O) NR6R7 alkyl and -C0-6- C (O) -C 1-6 alkyl; and R2b is selected from hydrogen, C1-3 alkyl, halo, hydroxyl, cyano, C1-3 haloalkyl, C1-3 alkoxy, and C0-6-S (O) alkyl-C1-alkyl 3; R3a is hydroxyl; R3b is selected from hydrogen, hydroxyl, halo, cyano, C1-3 haloalkyl, C1-3 hydroxyalkyl, C1-3 alkoxy, and -S (O) C1-3 alkyl; R4 is hydrogen or C1-3alkyl; R5 is hydrogen or C1-3alkyl; R6 is hydrogen or -C 1-6 alkyl; R7 is hydrogen or -C 1-6 alkyl; R8 is hydrogen or -C 1-6 alkyl; p is 0 or an integer of 1 or 2; q is 0 or an integer of 1 or 2; with the proviso that the compound of formula (I) is not 6- (2 - ((4-amino-3- (3-hydroxyphenyl) -1H-pi |
| priorityDate | 2009-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 492.