| abstract |
A compound according to formula (I): wherein: A1 is Gly, Acc, Aib, A1a or ß-Ala or Acc; A2 is Ser, Aib, Ala, Acc, Abu, Act, Ava, Thr or Val; A3 is Ser, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH -R7), Glu (O-R6), Ser (C (O) -R4), Thr (C (O) -R5) or HN-CH ((CH2) nN (R12R13)) - C (O); A4 is Phe, Acc, Aic, Cha, 2-Fua, 1-Nal, 2-Nal, 2-Pal, 3-Pal, 4-Pal, hPhe, (X1, X2, X3, X4, X5) Phe, Taz , 2-Thi, 3-Thi, Trp or Tyr; A5 is Leu, Abu, Acc, Aib, Ala, Cha, Ile, hLeu, Nle, Nva, Phe, Tle or Val; A6 is Ser, Abu, Acc, Act, Aib, Ala, Gly, Thr or Val; A7 is Pro, Dhp, Dmt, 3-Hyp, 4-Hyp, Inc, Ktp, Oic, Pip, Thz or Tic; A8 is Glu, Acc, Aib, Arg, Asn, Asp, Dab, Dap, Gln, Lys, Orn or HN-CH ((CH2) n-N (R12R13)) -C (O); A9 is His, Apc, Aib, Acc, 2-Fua, 2-Pal, 3-Pal, 4-Pal, (X1, X2, X3, X4, X5-) Phe, Taz, 2-Thi or 3-Thi; A10 is Gln, Acc, Aib, Asn, Asp or Glu; A11 is Arg, Apc, hArg, Dab, Dap, Lys, Orn or HN-CH ((CH2) n-N (R12R13)) - C (O); A12 is Val, Abu, Acc, Aib, Ala, Cha, Nva, Gly, Ile, Leu, Nle or Tle; A13 is Gln, Acc, Aib, Asn, Asp or Glu; A14 is Gln, Acc, Aib, Asn, Asp or Glu; A15 is Arg, hArg, Acc, Aib, Apc, Dab, Dap, Lys, Orn, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Cys (R15), hCys (SR16) , hCys (R17), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH-R7), Glu (O-R6), Ser (C (O) -R4 ), Thr (C (O) -R5) or HN-CH ((CH2) nN (R12R13)) - C (O); A16 is Lys, Acc, Aib, Apc, Arg, hArg, Dab, Dap, Orn, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Cys (R15), hCys (S25 R16 ), hCys (R17), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH-R7), Glu (O-R6), Ser (C (O) - R4), Thr (C (O) -R5), HN-CH ((CH2) nN (R12R13)) - C (O) or deleted; A17 is Glu, Arg, Asn, Asp, Dab, Dap, Gln, Lys, Orn, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Cys (R15), hCys (SR16) , hCys (R17), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH-R7), Glu (O-R6), Lys (biotinyl), Ser (C (O) -R4), Thr (C (O) -R5), HN-CH ((CH2) nN (R12R13)) - C (O) or deleted; A18 is Ser, Abu, Acc, Act, Aib, Ala, Thr, Val, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Cys (R15), hCys (S-R16) , hCys (R17), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH-R7), Glu (O-R6), Ser (C (O) -R4 ), Thr (C (O) -R5), HN-CH ((CH2) nN (R12R13)) - C (O) or deleted; A19 is Lys, Acc, Aib, Apc, Arg, hArg, Dab, Dap, Orn, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Cys (R15), hCys (SR16) , hCys (R17), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH-R7), Glu (O-R6), Ser (C (O) -R4 ), Thr (C (O) -R5), HN-CH ((CH2) nN (R12R13)) - C (O) or deleted; A20 is Lys, Acc, Aib, Apc, Arg, hArg, Dab, Dap, Orn, Asp (NH-R9), Asp (O-R8), Cys (S-R14), Cys (R15), hCys (SR16) , hCys (R17), Dab (S (O) 2-R11), Dap (S (O) 2-R10), Glu (NH-R7), Glu (O-R6), Ser (C (O) -R4 ), Thr (C (O) -R5), HN-CH ((CH2) nN (R12R13)) - C (O) or deleted. |