abstract |
A compound of formula Ia, or one of its pharmaceutically acceptable salts, solvates, hydrates, stereoisomers or tautomers: wherein X is S Y is NR5; Z is> = O, CO2R6, or C1-6 alkyl optionally substituted with aryl, hydroxy, carboxy, alkoxy, carbamoyl or halogen; R1 and R2 are each independently halogen, C1-6 alkyl or C1-6 halogenoalkyl; R3 is CN; R4 is hydrogen, R5 is hydrogen or C1-6 alkyl; and R6 is hydrogen or C1-6 alkyl. |