abstract |
An isolated human interleukin variant (hIL-15) comprising an amino acid substitution of N to D at position 72 of a mature human IL-15 sequence (SEQ ID NO: 1), wherein the hIL-15 variant It functions as an IL-15 agonist and has an increased binding activity for the beta / gamma chain receptors of the interleukin 15 receptor (IL-15RβγC) compared to the native IL-15 polypeptide. |