| abstract |
A compound having the formula: where V is oxygen or a single bond; W is C1-C6 alkylene; X is oxygen or sulfur; Y is a member selected from the group consisting of C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C1- alkyl C3, (C2-C4 alkenyloxy) C1-C3 alkyl and (C3-C10 cycloalkyloxy) C1-C3 alkyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups or moieties of Y are optionally partially or completely fluorinated and optionally are mono- or disubstituted with identical or different substituents selected from chloro, hydroxy, C1-C3 alkyl and C1-C3 alkoxy, and in the cycloalkyl and cycloalkenyl groups or portions of Y, optionally one or two methylene groups are replaced independently of each other with O, S, CO, SO, SO2 or NRb, and optionally one or two methine groups are replaced with N, wherein the heterocycle formed by said optional replacement is other than heteroaryl; R1 is selected from the group consisting of hydrogen, halo, C1-C6 alkyl, and C3-C10 cycloalkyl; R3 is selected from the group consisting of hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkyloxy, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, and C3-C10 cycloalkyloxy, where the groups or portions alkyl and cycloalkyl of R3 are optionally partially or completely fluorinated, and in cycloalkyl groups of R3 a methylene group is optionally replaced with O, S, CO, SO or SO2; and each Rb is a member independently selected from the group consisting of H, C1-C4 alkyl, and (C1-C4 alkyl) carbonyl, where the alkyl groups or moieties of Rb are optionally partially or completely fluorinated; or a pharmaceutically acceptable salt thereof. |