| abstract |
A compound of formula I: ** Formula ** or its pharmaceutically acceptable salts in which: A is a 4- to 7-membered nitrogen-containing heterocycloalkyl or, alternatively, A 5 can be condensed directly with the ring to which it is attached by R1; L is C1-3 alkyl; R1 is hydrogen, C1-3 alkyl or C3-4 cycloalkyl; each R2 is in each case C1-3 alkyl, fluorine, hydroxyl, C1-3 alkoxy or cyano; R3 is hydrogen, C1-3 alkyl or C3-4 cycloalkyl; R4 is a 5- to 10-membered heteroaryl with 1 to 3 heteroatoms, substituted where appropriate with 1 to 3 R7 substituents; R5 is hydrogen or -N (R8) 2; R6 is hydrogen, halogen or C1-3 alkyl; each R7 15 is independently halogen, - (CH2) tF, C1-3 alkyl, -CF3, - (CH2) C3-4 t-cycloalkyl, - (CH2) tO-C1-3 alkyl, - (CH2) t-cyano or - (CH2) t-hydroxy; Z is N or CR9; each R8 is independently hydrogen or C1-3 alkyl; R9 is hydrogen, C1-3 alkyl or halogen; m is 0, 1 or 2; n is 0, 1 or 2; t is 0, 1 or 2. |