abstract |
Two to four week long acting microsphere, comprising ({5- [2 - ({[(1E) -phenyl (pyridin-3-yl) methylene) amino} oxy) ethyl) -7,8-dihydronaphthalen- 1-11} oxy) acetic or its salt as a drug and a copolymer of lactic acid / glycolic acid, in which (i) an amount of copolymer of lactic acid / glycolic acid in parts by weight of the drug is from 3 to 10 parts by weight, (ii) the microsphere has an average particle tamer) of from 20 to 50 μm, and (iii) the lactic acid / glycolic acid copolymer has a weight average molecular weight of from 10,000 to 50,000 and a composition ratio of lactic acid / glycolic acid from 75/25 to 50/50, and which satisfies at least one of the following conditions (1) to (2): (1) a remaining ratio of the drug after one hour in a release test is at least 90%; (2) a remaining reason for the drug after one day in a release test is at least 82%. |