abstract |
The present invention relates to cyclophanic bis-pyridinium derivatives of general formula I, where L is a group of formula II, where Q is the conjugate base of an organic or inorganic acid and has a negative charge q; A and B are independently selected from a spacer group C {sub, 2} -C {sub, 15}; R {sup, 1} and R {sup, 2} are independently selected from hydrogen, halogen, C {sub, 1} -C {sub, 10} alkyl, C {sub, 1} -C {sub, 10} haloalkyl , amino, C {sub, 1} -C {sub, 10} alkylamino, hydroxy or C {sub, 1} -C {sub, 10} alkoxy; X {sup, 1} and X {sup, 2} are independently selected from NH, NR {sup, 3}, O, S and CH {sub, 2}. In addition, the present invention also protects a method of obtaining them, as well as their use as anti-protozoan drugs for the treatment and / or prevention of diseases caused by trypanosomatids, such as leishmaniasis. |