http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2458106-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb66d9373d09efad73c142762f6dfb00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 |
| filingDate | 2005-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_078811e771195dfc4bc2691c78baab08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a9c17a7374ac86bce3628ee53e71135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_712b7799b76cfdf5db30cd6ee8e3e878 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8b9ab2405fd8c5bbb363e5a40b4a3a6 |
| publicationDate | 2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2458106-T3 |
| titleOfInvention | Procedure for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines |
| abstract | Process for the preparation of a medicament, which comprises the use of a compound of the general formula (I), ** Formula ** or one of its enantiomers or salts, in which R1 means a phenylcarbonylmethyl, benzyl, naphthylmethyl group, pyridinylmethyl, pyrimidinylmethyl, quinolinylmethyl, isoquinolinylmethyl, quinazolinylmethyl, quinoxalinylmethyl, naphthyridinylmethyl or phenanthtridinylmethyl, where in each case the aromatic or heteroaromatic part is mono- or di-substituted with Ra, and the substituents may be the same or different at the same or different atoms. hydrogen, fluorine, chlorine or bromine or a cyano, methyl, trifluoromethyl, ethyl, phenyl, methoxy, difluoromethoxy, trifluoromethoxy or ethoxy group, or two Ra radicals, provided they are attached to adjacent carbon atoms, can also represent a -O group -CH2-O- or -O-CH2-CH2-O-, R2 a methyl, ethyl, propyl, isopropyl, cyclopropyl or phenyl group and R3 a 2-buten-1-yl, 3-methyl-2-buten- group 1-yl, 2-butin-1-yl or, 2-fluorobenzyl, 2-chlorobenzyl, 2-bromobenzyl, 2- iodobenzyl, 2-methylbenzyl, 2- (trifluoromethyl) benzyl or 2-cyanobenzyl, according to a procedure comprising the following synthesis steps: a) reaction of a compound of the general formula (III) ** Formula ** in which X means an output group selected from the group of halogens or sulphonic acid esters and R1 to R3 are defined as defined above, with 3- (phthalimido ) piperidine or one of its enantiomers, b) deprotection of the compound of the formula (II) obtained in this way ** Formula ** in which R1 to R3 are defined as mentioned above and c) eventually conversion into a physiologically tolerable salt ; and possibly one or several support substances and / or inert diluting agents. |
| priorityDate | 2004-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 139.