http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2455266-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 |
| filingDate | 2010-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc1b58f4f9603395c75ae2c2c2b0c2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_027b02953f27c8fe8bf305ffa3b10a8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df9d7e996793a85d4a746fdaa693d97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e6de93399b16fca8512d7b71b40edec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1f8a369915641529fb573156f80434c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5da5dea38a5b59e4f438b848a75314c5 |
| publicationDate | 2014-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2455266-T3 |
| titleOfInvention | Bicyclic heterocycles and their use as CCR2 receptor antagonists |
| abstract | A compound with the formula (I) ** Formula ** in which A is aryl, heteroaryl, arylmethyl or heteroarylmethyl, in which said rings are optionally substituted by one to three substituents independently selected from the group including a halogen, aryl, heteroaryl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy; E is CH2 or O; F is CH2, O, N (R8), S, SO or SO2; G is a single bond, CH2, or CH2CH2, with the proviso that when E is O then F is not O, S, SO, or SO2; L is a bond, NH-C (> = O), NH-C (> = S), or CH> = CH-C (> = O); R1, R2 and R3 are independently selected from the group including: - hydrogen, - C1-6alkyl, which is optionally substituted by one to three substituents independently selected from the group including hydroxy, C1-alkoxy -6, carboxy, carbamoyl, aminocarbonyl mono or substituted by C1-6alkyl and C1-6alkoxycarbonyl, aryl and heteroaryl, wherein said heteroaryl and aryl rings are optionally substituted by one to three substituents independently selected from the group including a halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy-C 3-7 cycloalkyl, or -aryl; R4 and R5 are independently selected from the group including: - hydrogen, - C1-6alkyl, which is optionally substituted by one to three substituents independently selected from the group including amino, hydroxy, carboxy, carbamoyl, aminocarbonyl mono or substituted by C1-6alkyl and C1-6alkoxycarbonyl, or -C3-7cycloalkyl, which is optionally substituted by one to three substituents independently selected from the group including amino, hydroxy, carboxy, carbamoyl, aminocarbonyl mono or substituted by C1-6alkyl and C1-6alkoxycarbonyl; or R4 and R5, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl or heterocyclyl which is optionally substituted by one to three substituents independently selected from the group including C1-4alkyl, haloalkyl C1-4 and a halogen; R6 and R7 are independently selected from the group it includes. |
| priorityDate | 2009-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 417.