http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2454567-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
filingDate | 2011-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2014-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0df9c079f9de136da185cb8d94e9793c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_453cafd6926786ff8b89146f133d05b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69815b392b0f584db6829ecff7780fee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b937a9897f4424246449a4e7cc2f267 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_820a067cfe7b807f1516ba80abbea2cd |
publicationDate | 2014-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2454567-T3 |
titleOfInvention | Phthalazin- (2h) -one kinase inhibitors |
abstract | A compound having formula (I) ** Formula ** in which R1a, R1b, and R1c are independently hydrogen, hydroxy, nitro, halogen, cyano, trifluoromethyl, trifluoromethoxy, C1-4alkyl, -ORa, or -NRbRc ; X is heteroaryl, which is optionally substituted with one or more R5; n is 0, 1, 2, or 3; with the proviso that when n is 1, 2, or 3, m is 0; m is 0, 1, 2, or 3; with the proviso that when m is 1, 2, or 3, n is 0; Y is a bond, -O-, -C (O) -, - (O) C-, -C (O) O-, -OC (O) -, -NRe-, -NReC (O) -, - C (O) NRe-, -NReC (O) NRf-, -SO2NRe-, or -NReSO2-; Z is C3-8 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, where C3-8 cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more R6; R5 is selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, heterocyclyl, halogen, oxo, cyano, nitro, -ORd, -C (O) Rd, -C (O ) ORd, -OC (O) Rd, -NReRf, -NReC (O) Rd, -NHC (O) NHRe, -NHSO2Rd, -C (O) NReRf, -SRd, -S (O) Rd, -SO2Rd, -SO2NReNRf, -B (OH) 2, -CF3, -CF2CF3, -OCF3, and -OCF2CF3 where (a) R5 C1-8alkyl, C2-8alkenyl, and C2-8alkynyl, substituents are optionally substituted with one or more substituents selected from the group consisting of aryl, heterocyclyl, C3-8 cycloalkyl, halogen, cyano, nitro, oxo, -ORg, -C (O) Rg, -C (O) ORg, -OC (O) Rg , -NRhRi, -NRhC (O) Rg, -NHSO2Rg, -NHC (O) NHRh, -C (O) NRhRi; and where (b) the aryl and heterocyclyl substituents of R5 are optionally substituted with one or more substituents independently selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, aryl, heterocyclyl, halogen, cyano , nitro, oxo, -ORj, -C (O) Rj, -C (O) ORj, -OC (O) Rj, -NRkRl, -NRkC (O) Rj, -NHC (O) NHRk, -NHSO2Rj, - C (O) NRkRl, -SRj, -S (O) Rj, -SO2Rj, -SO2NRkNRl, -CF3, -CF2CF3, -OCF3, and -OCF2CF3; R6 is selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, heterocyclyl, halogen, oxo, cyano, nitro, -ORd, -C (O) Rd, -C (O ) ORd, -OC (O) Rd, -NReRf, -NReC (O) Rd, -NHC (O) NHRe, -NHSO2Rd, -C (O) NReRf, -SRd, -S (O) Rd, -SO2Rd, -SO2NReNRf, -B (OH) 2, -CF3, -CF2CF3, -OCF3, and -OCF2CF3 where (a) R6 C1-8alkyl, C2-8alkenyl, and C2-8alkynyl, substituents are optionally substituted with one or more substituents selected from the group consisting of aryl, heterocyclyl, C3-8 cycloalkyl, halogen, cyano, nitro, oxo, -ORg, -C (O) Rg, -C (O) ORg, -OC (O) Rg , -NRhRi, -NRhC (O) Rg, -NHSO2Rg, -NHC (O) NHRh, -C (O) NRhRi; and where (b) the aryl and heterocyclyl substituents of R6 are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, C2-8-alkenyl, aryl, heterocyclyl, halogen, cyano , nitro, oxo, -ORj, -C (O) Rj, -C (O) ORj, -OC (O) Rj, -NRkRl, -NRkC (O) Rj, -NHC (O) NHRk, -NHSO2Rj, - C (O) NRkRl, -SRj, -S (O) Rj, -SO2Rj, -SO2NRkNRl, -CF3, -CF2CF3, -OCF3, and -OCF2CF3; Ra, at each occurrence, are selected from the group consisting of hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, aryl, heterocyclyl, and C3-8cycloalkyl, where C1-8alkyl, C2alkenyl -8, C2-8alkynyl, aryl, heterocyclyl, and C3-8cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C1-8alkyl, aryl, heterocyclyl, C3-8cycloalkyl, halogen, cyano , oxo, hydroxy, C1-8 alkoxy, -NH2, -NH (C1-8 alkyl), -O (C1-8 alkyl) NH2 and -N (C1-8 alkyl) 2. |
priorityDate | 2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1029.