| abstract |
Compound of formula (I) ** Formula ** or a stereoisomeric form thereof, wherein: R1 is hydrogen, cyano, CF3, halo or C1-4alkyl optionally substituted with one or more substituents each independently selected from the group that it consists of hydroxyl and C1-4 alkyloxy; R2 is hydrogen, C1-4alkyl or halo; X is CR5 or N; R5 is hydrogen or halo; A1 is CR6 or N; R6 is hydrogen, halo or C1-4 alkyloxy; A2, A3 and A4 are each independently CH, CF or N; provided that not more than two of A1, A2, A3 and A4 are N; Y1 is CH or N; Y2 is CR4 or N; Y3 is CH or N; provided that only one of Y1, Y2 and Y3 can represent N; R4 is hydrogen, halo, C1-4alkyloxy, cyano, C3-7cycloalkyl, C2-4alkenyl or C1-4alkyl optionally substituted with one or more substituents each independently selected from the group consisting of halo and C1-4alkyloxy; R3 is C2-6alkyl substituted with one or more halo substituents; C 1-6 alkyl optionally substituted with one or more substituents each independently selected from the group consisting of piperidinyl, morpholinyl, pyrrolidinyl, Ar, C 1-6 alkyloxy, tetrahydropyranyl, C 3-7 cycloalkyloxy and C 3-7 cycloalkyl; C3-7 cycloalkyl substituted with one or more phenyl substituents optionally substituted with one or more halo substituents; C3-7 cycloalkyl; piperidinyl; morpholinyl; pyrrolidinyl; tetrahydropyranyl; O-Ar; NR7R8; C1-6 alkyloxy; C1-6alkylthio; Ar; CH2-O-Ar; He; NCH3-Ar; NH-Ar; or 1,6-dihydro-1-methyl-6-oxo-3-pyridinyl; wherein each piperidinyl, morpholinyl, and pyrrolidinyl may be substituted with one or more substituents each independently selected from the group consisting of C1-4alkyl, C2-6alkenyl, C1-4alkylcarbonyl, halo, and C1-4alkyloxycarbonyl. |