abstract |
Compound of formula IK: ** Formula ** and N-oxides, hydrates, solvates, pharmaceutically acceptable salts or complexes thereof and racemic and yescalemic mixtures, diastereomers and enantiomers thereof, where X is aryl optionally substituted with one, two or three hydroxyl, -O-C1-C3-alkyl, amino, -NR3R4, -CN, -CF3, -C1-C4-alkyl, -S (O) 0-2R5, -O-CF3 or halo selected independently, Y is -NH2 or - OH; Ra is H or F; Z is phenyl, heteroaryl, heterocyclyl, or cycloalkyl; R is R9- (C0-6 alkyl) NC (O) -N (H) - (CH2) t-, C0-6-alkyl (S) O-2-N (H) -phenyl-C (O) -N (H) - (CH2) t-, R9-OC (O) -N (H) - (CH2) t- or R9-OC (O) - (CH2) t- where t is 0-2; and R9 is R10-C0-C2-alkyl-, wherein R10 is 5- or 6-membered aryl, heterocyclyl or heteroaryl or N (X1) (X2) -C0-3alkyl-, and where X1 and X2 are independently H, C1-C4-alkyl or 5- or 6-membered heteroaryl, provided that when R10 is heterocyclyl linked through the N atoms, then R9 is R10-C2-alkyl-; and wherein R3 and R4 are independently selected from the group consisting of -C2-C3-alkyl-OR5, -C (O) -aryl, -C1-C3-alkoxy-C1-C3-alkyl, -C2-C3-O-alkyl- C1-C3 alkyl, -C2-C3-NR5R6 alkyl, -CH2-C (CH3) 2-NR5R6, in which aryl and heteroaryl are optionally substituted with one, two or three amino, methoxy, hydroxyl, -S-CH2-heteroaryl , -NR3S (O) 2-C1-C3-alkyl. |