http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2451627-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_129e393582e6bdf4029baf2206522f45 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5585 |
| filingDate | 2006-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_042465e998f3f9becf20d2cc04b728bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cdb344a62e20172339264d2c28f6f41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5566b7ff06c548b7808f748c0423a891 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d984b19638fb10599bec37a66dee10d |
| publicationDate | 2014-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2451627-T3 |
| titleOfInvention | Therapeutic agent and treatment method to improve uremia |
| abstract | Substance for use in the treatment of uremia in patients suffering from chronic renal failure, in which said substance comprises, as an effective ingredient, a compound of general formula (I): ** Formula ** [in which R1 is (A) COOR2, wherein R2 is 1) hydrogen or a pharmaceutically acceptable cation, 2) C1-C12 linear alkyl or C3-C14, 3) -Z-R3 branched alkyl, wherein Z is a covalent bond, or linear alkylene or branched represented by CtH2t in which t is an integer from 1 to 6, R3 is C3-C12 cycloalkyl or C3-C12 cycloalkyl substituted with 1 to 3 R4 in which R4 is hydrogen or C1-C5 alkyl, 4) - (CH2CH2O ) nCH3, in which n is an integer from 1 to 5, 5) -Z-Ar1, in which Z represents the same meanings as described above, Ar1 is phenyl, a-naphthyl, b-naphthyl, 2 -pyridyl, 3-pyridyl, 4-pyridyl, a-furyl, b-furyl, a-thienyl, b-thienyl or substituted phenyl (in which the substituent or substituents are at least one d and chlorine, bromine, fluorine, iodine, trifluoromethyl, C1-C4 alkyl, nitro, cyano, methoxy, phenyl, phenoxy, p-acetamidabenzamide, -CH> = N-NH-C (> = O) -NH2, -NH- C (> = O) -Ph, -NH-C (> = O) -CH3 and-NH-C (> = O) -NH2), 6) -CtH2tCOOR4, in which CtH2t and R4 represent the same meanings as described above, 7) -CtH2tN (R4) 2, in which CtH2t and R4 represent the same meanings as described above, 8) -CH (R5) -C - (> = O) -R6, in that R5 is hydrogen or benzoyl, and R6 is phenyl, p-bromophenyl, p-chlorophenyl, p-biphenyl, pnitrophenyl, p-benzamidaphenyl or 2-naphthyl, 9) -CpH2p-W-R7, where W is -CH > = CH-, -CH> = CR7- or -C≡C-, in which R7 is hydrogen, linearly branched C1-C30 alkyl or C7-C30 aralkyl, p is an integer from 1 to 5, or 10) -CH (CH2OR8) 2, where R8 is C1-C30 alkyl or acyl, (B) -CH2OH, (C) -C (> = O) N (R9) 2, where R9 is hydrogen, linear alkyl C1-C12, branched C3-C12 alkyl, C3-C12 cycloalkyl, C4-C13 cycloalkylalkylene, phenyl, substituted phenyl (in the that the definition or definitions of the substituent or substituents are the same as those described in (A) 5 above), C7-C12 or -SO2R10 aralkyl in which R10 is C1-C10 alkyl, C3-C12 cycloalkyl, phenyl, phenyl substituted (in which the definition or definitions of the substituent or substituents are the same as those described in (A) 5) mentioned above), or aralkyl C7-C12, in which the two R9 may be the same or different, with the proviso that when one of them is -SO2R10, the other R9 is not -SO2R10, or (D) -CH2OTHP (where THP is tetrahydropyranyl), A is 1) - (CH2) m-, 2) -CH> = CH-CH2-, 3) -CH2-CH> = CH-, 4) -CH2-O-CH2-, 5) -CH> = CH-, 6) -O-CH2- or 7) -C≡C- , in which m is an integer from 1 to 3. |
| priorityDate | 2005-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 333.