| abstract |
A compound or a pharmaceutically acceptable salt thereof, of Formula I: ** Formula ** in which: X1 is O or S; X2 is 0; R1 is H; R2 is H, halo, -CN, -CF3, -NO2, C0-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, C0-12 alkyl, heterocycle C3-12 alkylC0-12 alkyl, C0-12 arylalkyl or C0-12 heteroarylalkyl, any of which is optionally substituted with one or more independent G2 substituents; or R2 is tetrahydropyridinyl, which is a structure of Formula II: ** Formula ** R3 is H; R4 is H, C0-12 alkyl, C3-12 cycloalkyl C0-12 alkyl, heterocycloalkyl C3-12 alkyl C0-12, arylalkyl C0-12, arylcycloalkyl C3-12, arylheterocycloalkyl C3-12, heteroarylalkyl C0-12, heteroarylcycloalkyl C3-12 oheteroaryl C3-12, any of which is optionally substituted with one or more independent G3 substituents; or R4 is - (CR10R11) nA1; A1 is aryl or heteroaryl optionally substituted with one or more independent G4. |