| abstract |
A topical administration composition in a pressurized container, said composition comprising: up to 15% w / w of at least one pharmaceutically active compound, wherein said at least one pharmaceutically active compound is clindamycin, or a pharmaceutically acceptable salt thereof or an ester of the same; from 83% to 97.9% w / w of a fast breaking foaming agent comprising a C1-C6 alcohol, a C14-C22 alcohol, water and surfactant; from 2% to 7% w / w of an aerosol propellant selected from the group consisting of a hydrocarbon, a chlorofluorocarbon, dimethyl ether, hydrofluorocarbons and a mixture thereof; and a pH adjusting agent that is a base and in which the pH adjusting agent is present in an amount sufficient to adjust the pH of the composition between pH 4.0 and pH 6.5. and wherein said composition is a temperature sensitive foam at rapid breakage after being released from said container. |