http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2450119-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 |
| filingDate | 2010-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e698493b7081e0866d522a049b201ae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d7de64bcb7da7a397ca2598d7c562db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_589e637640a348954dfd7929f1080661 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd070dc1092560eabbc7c33bb65af3aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1f654ec66a622f878ccae27106181be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d2e92cf4711c6a42494f81603f2bd2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4535a4eae8bb559ed558aea0639c638c |
| publicationDate | 2014-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2450119-T3 |
| titleOfInvention | Azocyclic spiroderivatives as HSL inhibitors |
| abstract | Compounds with the formula (I) ** Formula ** in which m is 1 or 2; n is zero, 1 or 2, where, in case n is zero, m is 1; A is -S (O) 2- or carbonyl; R1 is alkyl, aminoalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haalkylcycloalkyl, hydroxycycloalkylalkyl, (cycloalkyl) (hydroxy) alkyl, (cycloalkyl) alkylokylakylakylakylakylakylakylaxy, alkyloxy, alkyloxy, alkyloxy, hydroxyalkyl, , dihydroisoindolyl, dihydroquinolinyl, -NR4R5, acepanyl, morpholinyl, piperidinyl, pyrrolidinyl, pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, thiophenyl, pyridinyl, pyridylanyl, pyridylanyl, pyridazinyl, pyridazinyl, pyridazinyl, pyridazinyl, pyridazinyl, pyridacinyl, pyridazinyl, pyridazinyl, pyridacinyl, pyridinyl, pyridinyl, pyridinyl, pyridycinyl, pyridinyl, pyridinyl, pyridylanyl, , substituted pyrrolidinyl, substituted pyrazolyl, substituted imidazolyl, substituted isoxazolyl, substituted oxazolyl, substituted thiophenyl, substituted thiazolyl, substituted pyridinyl, substituted pyridinylalkyl, substituted pyridacinyl, substituted pyridacinylalkyl, substituted pyrazinyl, substituted pyrazinylalkyl, substituted pyrimidyl, substituted pyrimidylalkyl, substituted phenyl, or substituted phenylalkyl, wherein substituted piperidinyl, substituted pyrrolidinyl, substituted pyrazolyl, substituted imidazolyl, substituted isoxazolylsyl, substituted thiophenyl, thiophenyl, thiophenyl substituted, substituted pyridinylalkyl, substituted pyridacinyl, substituted pyridacinylalkyl, substituted pyrazinyl, substituted pyrazinylalkyl, substituted pyrimidyl, substituted pyrimidylalkyl, substituted phenyl or substituted phenyl-alkyl are independently selected from three substituents. alkyl, haloalkyl, a halogen, hydroxy, alkoxy, haloalkoxy, phenyloxy, alkylphenyloxy, alkylsulfonyl, oxopyrrolidinyl, alkoxycarbonyl, benzyloxy, and -NR6R7; R2 is imidazolyl, imidazolylalkyl, phenyl, phenylalkyl, pyridinyl, pyridinylalkyl, pyridacinyl, pyridacinylalkyl, pyrazolyl, pyrazylalkyl, alkyldindazolyl, alkylbenzothiazolyl, pyrimidyl, pyrimidyl, pyrimidyl, pyrimidyl, pyrimidyl, pyridinyl, pyridylanyl, pyrimidyl, pyrimidyl, pyrimidyl, pyridyl, pyridinyl, pyrimidyl, pyrimidyl, pyrimidyl, pyrimidyl, pyrimidyl, pyrimidyl, pyrimidyl, pyridinyl, pyridyl, pyridyl, pyridyl, pyridyl, pyridylamino, pyrimidyl, pyrimidyl, aryl , substituted phenylalkyl, substituted pyridynyls, substituted pyridynylalkyl, substituted pyridacinyl, substituted pyridacinylalkyl, substituted pyrazylalkyl, substituted pyrimidyl, substituted pyrimidylalkyl, substituted, pyrazinyl, substituted, substituted, substituted substituted pyridinyl, substituted pyridynylalkyl, substituted pyridacinyl, substituted pyridacinylalkyl, substituted elpyrazolyl, substituted pyrazolylalkyl, substituted pyrimidyl, substituted pyrimidylalkyl, pi racinilosustituido and substituted pyrazinylalkyl are replaced by one to three substituents which are independently selected from alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkoxy, alkoxy, hydroxy, alkoxyalkyl, hydroxyalkyl, alkylsulfonyl, alkylsulfonyloxy, alkylsulfanyl, cicloalquilsulfoniloxilo, cycloalkoxy, alkenyl, cycloalkylalkoxy, alkoxyalkoxy, tetrahydrofuranyloxy, piridiniloxilo, alkoxycarbonylalkyl, cyanoalkyl, alquiloxazodiazolilalquilo, haloalquiloxazodiazolilalquilo, alkoxyalkenyl, cycloalkylalkenyl, cycloalkylalkoxyalkyl, alkoxycarbonyl, alkylcarbonyl, haloalquilhidroxialquilo, alkylaminocarbonyl, dialkylaminocarbonyl, hidroxioxetanilo, fluorooxetanilo and hydroxycycloalkyl; one of R4 and R5 is hydrogen or alkyl and the other is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, phenyl, alkylphenyl, haloalkoxyphenyl, phenylalkyl, halophenyl alkyl, haloalkylphenyl or pyridinylalkyl; one of R6 and R7 is hydrogen, or hydroxyalkyl and the other is hydrogen, alkyl, cycloalkyl or hydroxyalkyl; or pharmacologically acceptable salts thereof. |
| priorityDate | 2009-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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