http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2448839-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2008-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e891f8e37c0cd4e0c43e74a827e95f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bd418c9d47f6edcf324c17c46401d7d |
| publicationDate | 2014-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2448839-T3 |
| titleOfInvention | Non-steroidal compounds useful as moderators of the activity of the glucocorticoid receptor AP-1 and / or NF-kappa b and their use |
| abstract | A compound with the structure of the formula (Ia) or (Ib): ** Formula ** or enantiomers, diastereomers, or pharmaceutically acceptable salts thereof, wherein: R1 is hydrogen, C1-3 alkyl, C2-3 alkenyl , C2-3 alkynyl, cyclopropyl, halogen, -CH2F, CHF2, -CF3, -CN, C1-3 alkoxy, -NRdRc, -C (O) ORd or -C (O) NRdRc; R2 is hydrogen or C1-3 alkyl; R3 is hydrogen, OH, F, Cl or C1-3 alkyl; R4 is i) hydrogen, ii) C1-3 alkyl optionally substituted with OH, F or phenyl, iii) C2-4 alkenyl or C2-4 alkynyl, iv) aryl or aryl substituted with one or more of halogen, C1-3 alkyl , methoxy and / or -CN, v) -CRaRbRc, -C (O) Rc, - (CH2) pC (O) NHRc, - (CH2) pNHRc, - (CH2) pNHC (O) ORc or - (CH2) pNHC (O) NHRc, in which p is zero, 1, 2 or 3, or vi) -CRaRbRc in which Rb and Rc together with the carbon atom to which they are attached form a heterocycle of 1 or 2 rings with at least one heteroatom chosen from N, O, and S; or R3 and R4 together with the carbon atom to which they are attached, form a saturated heterocyclic ring of 5 to 7 members with between 1 and 2 heteroatoms independently selected from between N, O and S; each R5 is independently C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl, C2-4 alkenyl, C2-4 alkynyl, F, Cl, -CN, C1-3 alkoxy and / or -OCF3; R6 is hydrogen, C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl, C2-4 alkenyl, C2-4 alkynyl, F, Cl, -CN, C1-3u alkoxy -OCF3; R7 is aryl or heterocycle optionally substituted with one or more of C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, CNy / or halogen; Ra is hydrogen, C1-3 alkyl or C1-3 alkyl substituted with OH or F; Rb is hydrogen, OH, C1-3 alkyl, C1-3 alkoxy or C1-3 alkyl substituted with OH or F; Rc is: i) C1-5 alkyl optionally substituted with OH, aryl or haloaryl, ii) C1-3 haloalkyl, C3-6 cycloalkyl or C2-4 alkenyl, iii) C2-4 alkynyl optionally substituted with aryl, iv) aryl optionally substituted with one or more of halogen, methoxy, -S (O) (C1-3 alkyl), -S (O) 2 (C1-3 alkyl), - CN, C1-3 alkyl, C1-3 hydroxyalkyl, C1 haloalkyl -3, saturated heterocycle and / or -S- (C1-3 alkyl), ov) aryl or heteroaryl of 1 or 2 rings optionally substituted with one or more of C1-4 alkyl, halogen, -C (O) OH, - C (O) O (C1-3 alkyl), -C (O) NH (C1-3 alkyl), or -C (O) N (C1-3 alkyl) 2; |
| priorityDate | 2007-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 965.