| abstract |
A new antibiotic and an anticancer compound of the general formula I, II, III or IV, derivatives, stereoisomers, the racemic or non-racemic mixture of the stereoisomers or the solvate or pharmaceutically acceptable salt of the compounds, the general Formula is shown as follows: wherein Y represents the benzene ring elements in any position, and can be independently selected from C, O, S and N; when Y means O or S, it is a bivalent element, Y is an electrotrivalent element when it means N, and is a tetravalent element when it means C, Y is preferably selected from C, N or S; dotted lines represent links that are expendable, when a link is a double link, its neighbor links are not double links; k is an integer 0 or 1; n is an integer 0, 1 or 2; R1, R2, R3 and R4 can be independently selected from hydrogen, fluorine, chlorine, bromine, iodine, hydroxyl, cyano, C1-20-alkyl, C1-20-alkyl-oxy, C1-20-alkyl carbonyl, and C1- 20-alkyl-carbonyl-oxy, provided that at least one of R1, R2, R3 and R4 is not hydrogen, and the alkyl portion in these groups can be replaced by one or more of the independent halogen atoms such as fluorine, chlorine, bromine and iodine; R5 represents hydrogen, C1-20-alkyl, C1-20-alkyl-oxy, C1-20-alkyl-carbonyl, or C1-20-alkyl-carbonyl-oxy; R7 represents hydrogen, alkyl, aryl, substituted aryl or heteroaryl; A1 represents CH2, CH2CH2, O, S, S (O), S (O) 2, or NR1; A2 represents Cl, Br, F or I; A3 represents O, S, S (O), S (O) 2, NR, Cl, Br, F, I or P; when A3 is Cl, Br, F or I, R7 does not exist. wherein C1-20-hydrocarbonyl is an aromatic hydrocarbonyl or non-aromatic hydrocarbonyl, straight chain hydrocarbonyl or branched chain hydrocarbonyl, cyclic hydrocarbonyl or noncyclic hydrocarbonyl group. |