http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2446249-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed28726de9f916f355f8adc331e736b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 2009-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_078ee40cce510e83ce626b12ea4ae8ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_782bf43a40f2e1f74cf5553ca2c34bd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4adab5cdf1922f5b15617c6dce1432d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d8d47143c8bdf0f06314502dab4adad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_268b24da04cabad8b28ed95fd8c7f0bc |
| publicationDate | 2014-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2446249-T3 |
| titleOfInvention | Inhibition of interaction between hif-1a and p300 / cbp with propellers based on hydrogen bond substitutes |
| abstract | A peptide of Formula (I) having one or more stable, internally restricted α-helices: ** Formula ** wherein R1 is an amino acid, a peptide, -OR4, -CH2NH2, an alkyl group, an aryl group, or hydrogen, R4 is alkyl or aryl; or R1 has the formula: ** Formula ** wherein A5 is a peptide, an amino acid residue, an acyl group, or hydrogen; and each R5 is independently an amino acid side chain, hydrogen, an alkyl group, or an aryl group; it is a carbon-carbon single bond or a carbon-carbon double bond that can be cis or trans; each n is independently 1 or 2; R2 is hydrogen, an amino acid side chain, an alkyl group, or an aryl group; m is any positive integer; A3 is ** Formula ** where R9 is an amino acid side chain; (i) A1 is Thr; A2 is Ser or Ala; A3 is Tyr or Ala; and A4 comprises the formula X1X2X3X4X5X6X7, wherein X1 is Asp or Asn, X2 is Val, Cys, or Ala, X3 is Glu or Gln, X4 is Val or Tyr, X5 is Asn or Arg, X6 is Ala, and X7 is Arg or is absent; or (ii) A1 and A2 are independently Glu or Gln; A3 is Leu; and A4 comprises the formula LRX8LX9, where L is Leu, R is Arg, X8 is Ala or Tyr, and X9 is Asp or Asn; and R3 is a peptide, -OR6, -N (R7) 2, an alkyl group, an aryl group, or hydrogen, wherein R6 is an alkyl group or an aryl group, and each R7 is independently an amino acid side chain, hydrogen , an alkyl group, or an aryl group; yen where the peptide modulates the interaction between C-TAD of HIF-1α and the CH1 domain of p300 / CBP. |
| priorityDate | 2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1086.