abstract |
A compound having the structure of the formula (I), or its pharmaceutically acceptable salt: ** Formula ** in which: R1 is -CO2H, -CO2RD, -CN, -C (> = O) N (R9) 2, -C (> = O) NHCH2CH2SO3H, or -C (> = O) NHSO2R10, tetrazolyl, 5 or 5-oxo-2,5-dihydro- [1,2,4] oxadiazol-3-yl; RD is H or C1-C4 alkyl; R3 is H, C1-C4 alkyl, C3-C6 cycloalkyl, or C1-C4 fluoroalkyl; R4 is -NR7C (> = O) OCH (R8) -CY; R7 is H or C1-C4 alkyl; R8 is H, C1-C4 alkyl, or C1-C4 fluoroalkyl; CY is a substituted or unsubstituted C3-C6 cycloalkyl or a substituted or unsubstituted phenyl, in which if CY is substituted, then CY is substituted with 1 or 2 RC; R9 is H, C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C6 cycloalkyl, or a substituted or unsubstituted phenyl; R10 is a C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C6 cycloalkyl, or a substituted or unsubstituted phenyl; each of RA, RB, and RC is independently selected from F, Cl, Br, I, -CN, -OH, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 fluoroalkoxy, C1-C4 alkoxy, and C1 heteroalkyl -C4; m is 0, 1, or 2; n is 1, 2, 3 or 4; p is 0, 1, or 2. |