http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2445536-T3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 |
filingDate | 2010-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2014-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b717b4b9822cfcdf3967eabcd267135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38a61045fdde70d96bd9778de3e49709 |
publicationDate | 2014-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2445536-T3 |
titleOfInvention | Derivatives of pyrazine and its use in the treatment of neurological disorders |
abstract | A compound of formula (I), or a pharmaceutically acceptable salt thereof, in which R 1 is hydrogen, cyano, halogen, (C 1-8) alkyl, halogen (C 1-8) alkyl, (C 1-8) alkoxy, halogen-C1-8 alkoxy, alkylthio (C1-8), halogen alkylthio (C1-8), alkoxy (C1-8) -alkyl (C1-8), alkoxy (C1-8) -alkoxy (C1- 8), (C1-8) alkoxy (C1-8) alkylthio (C1-8) alkylthio (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) ) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl (C2-8); R2 is a non-aromatic aryl, heteroaryl or heterocyclic group G1, group G1 which is optionally substituted by 1 to 4 substituents independently selected from the group, consisting of cyano, amino, aminocarbonyl, halogen, (C1-8) alkyl, halogen-alkyl (C1-8), hydroxy, oxo, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, halogen (C1-8) alkyl, (C1-8) alkoxy (C1-8), (C1-8) alkoxy (C1-8) alkoxy, (C1-8) alkoxy (C1-8) alkylthio (C1-8) alkylthio (C1-8) alkyl, alkylthio ( C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), alkynyl (C2-8), alkenoxy (C2-8), alkyloxy (C1 -8) and a cycloalkyl (C3-8), aryl, heteroaryl or non-aromatic heterocyclic group G2, group G2 which is optionally substituted by 1 to 4 substituents independently selected from the group, consisting of decian, aminocarbonyl, halogen, (C1-) alkyl 8), halogen (C1-8) alkyl, hydroxy, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, halogen-al chylthio (C1-8), alkoxy (C1-8) -alkyl (C1-8), alkoxy (C1-8) -alkoxy (C1-8), alkoxy (C1-8) -alkylthio (C1-8), alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8) and alkynyl ( C2-8); R3 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, (C1-8) alkoxy; halogen-C1-8 alkoxy, alkylthio (C1-8), halogen alkylthio (C1-8), alkoxy (C1-8) -alkyl (C1-8), alkoxy (C1-8) -alkoxy (C1- 8), (C1-8) alkoxy (C1-8) alkylthio (C1-8) alkylthio (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) ) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl (C2-8); Either R4 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, alkoxy (C1-8), halogen-C1-8 alkoxy, alkylthio (C1-8), halogen- (C1-8) alkylthio (C1-8) alkoxy (C1-8) alkyl, (C1-8) alkoxy (C1-8) alkoxy, (C1-8) alkoxy (C1-8) alkylthio, alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl (C2-8); and R5 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, alkoxy (C1-8), halogen-alkoxy (C1-8), alkylthio (C1-8), halogen- (C1-8) alkylthio (C1-8) alkoxy (C1-8) alkyl, (C1-8) alkoxy (C1-8) alkoxy, (C1-8) alkoxy (C1-8) alkylthio, alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C1-8), or alkynyl (C1-8); or R4 and R5, taken together, are -C (H)> = C (H) -C (H)> = C (H) - or an alkylene group (C1-8), wherein 1 or 2 members of the -CH2- ring of the (C1-8) alkylene group, are optionally replaced with heteroindependently selected ring members of the group, consisting of -N (H) -, -N [C1-8 alkyl )] -, -O-, -S-, -S (> = O) - or -S (> = O) 2-. |
priorityDate | 2009-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 640.