http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2443519-T3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_989ad716559b7e5b8527e7324699ed6e |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
filingDate | 2007-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ed1389b68662605734974838a7ea4d2 |
publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2443519-T3 |
titleOfInvention | Irreversible tyrosine kinase protein inhibitors and the methods of preparation and uses thereof |
abstract | A compound of formula (I), or a hydrate or a pharmaceutically acceptable salt thereof, ** Formula ** where X represents N, C-CN, or CH; Y represents CH2, S, O, or N-R9; R1, R3, R7 and R8 independently represent H, CF3, or C1-6 alkyl; R2 represents a group selected from formulas (II), (III), (IV), (V), (VI), (VII), or (VIII); ** Formula ** R4 and R6 independently represent H, alkyl C1-6, C1-6alkyl, OH, F, CI, Br, OCF3, or trifluoromethyl; R5 is independently selected in each case from H, F, C1-6 alkyl, OH, C1-6alkyl, OCF3, OCF2CH3, NH2, NH (C1-6 alkyl), N (C1-6 alkyl) 2, 1-pyrrolinyl, 1-piperidyl, 4-morpholinyl, CI, Br, trifluoromethyl, O (CH2) 2-4 C1-6alkyl, O ( CH2) 2-4OCF3, O (CH2) 2-4NH (C1-6 alkyl), O (CH2) 2-4N (C1-6 alkyl) 2, (1-pyrrolinyl) (CH2) 2-4O, (1- piperidyl) (CH2) 2-4O, (4-morpholinyl) (CH2) 2-4O, NHC (O) H, NHC (O) (C1-6 alkyl), N (C1-6 alkyl) C (O) ( C1-6 alkyl), O (CH2) 2-4OH, N (C1-6 alkyl) C (O) O (C1-6 alkyl), N (C1-6 alkyl) C (O) OH, NHC (O) Oalkyl C1-6, OC (O) NH (C1-6 alkyl), OC (O) N (C1-6 alkyl) 2, (1-piperidyl) (CH2) 2-4OC (O), (4-morpholinyl) ( CH2) 2-4OC (O), (1-pyrrolinyl) (CH2) 2-4OC (O), (1-imidazolyl) (CH2) 2-4O, (pyrazolyl) (CH2) 2-4O, (triazolyl) ( CH2) 2-4OC (O), or Ar (CH2) 1-4O; R9 are each independently selected from H, C1-6 alkyl, CF3, CF2CH3, (CH2) 2-4OH, (CH2) 1-4 C1-6alkyl, (CH2) 1-4NH (C1-6 alkyl), (CH2) 1-4N (C1-6 alkyl) 2, (1-pyrrolinyl) (CH2) 1-4, (1-piperidyl) (CH2) 1-4, (4-morpholinyl) (CH2) 1-4, C (O ) C1-6 alkyl, C (O) (CH2) 1-4OH, C (O) (CH2) 1-4 C1-6 alkyl, C (O) (CH2) 1-4N (C1-6 alkyl) 2, ( 1-pyrrolinyl) (CH2) 1-6C (O), (1-piperidyl) (CH2) 1-6C (O), (4-morpholinyl) (CH2) 1-4C (O), C (O) C1 alkyl -6, C (O) O (CH2) 2-4 C1-6 alkyl, C (O) O (CH2) 2-4N (C1-6 alkyl) 2, (1-pyrrolinyl) (CH2) 2-4OC (O ), (1-piperidyl) (CH2) 2-4OC (O), (4-morpholinyl) (CH2) 2-4OC (O), (CH2) 1-4C (O) C1-6alkyl, or Ar (CH2 ) 1-4; R10 represents H, C1-6 alkyl, or one or two F. |
priorityDate | 2006-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 262.