| abstract |
A compound of the following formula: ** Formula ** and / or a pharmaceutically acceptable salt thereof, wherein each of R1, R2 and R5, is independently H, halo, nitro, amino, cyano, hydroxy, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkoxy, alkylthio, alkylcarbonyl, carboxy, alkoxycarbonyl, carbonylamino, sulfonylamino, aminocarbonyl, or aminosulfonyl; one of R3 and R4 is ** Formula ** in which n is 1, 2, 3, 4, or 5; each of Ra, Rb, and Rc, is independently H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, or Rb and Rc, together with the nitrogen atom to which they are attached, form a 3- ring 12 saturated, unsaturated or aromatic members containing 1-3 heteroatoms selected from N, O and S; and each of Rd and Re, is independently H, alkyl, alkenyl, or alkynyl; oRd and Re together with the nitrogen to which they are attached, form a saturated, unsaturated or aromatic 3-12 membered ring containing 1-3 heteroatoms selected from N, O and S; and the other of R3 and R4 is H, halo, nitro, amino, cyano, hydroxy, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkoxy, alkylthio, alkylcarbonyl, carboxy, alkoxycarbonyl, carbonylamino, sulfonylamino, aminocarbonyl, oaminosulfonyl; X is O, S or NRf, wherein Rf is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, or aminosulfonyl; Y is phenyl substituted with alkynyl, or fused with another 3-8 membered ring; Z is N or C-CN. |