abstract |
A compound having the structure: ** Formula ** in which: Z1-Z6 are each independently C, N, O, or S, with the proviso that at least one of Z1-Z6 is N; 5 n and m are each independently 1 to 5; p is 0 or 1; each R1 and R2 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halide, hydroxy, alkoxy, trifluoromethyl -N (R6) 2, -CN, -CO2R6 or -CH2OH; or when n is 2, each R1 taken together with the carbon atoms to which they are attached forms a fused aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclic or substituted heterocyclic ring; R3, R4, R5 and R6 are each independently H or C1-C6 alkyl; or pharmaceutically acceptable salts thereof. |