http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2442179-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 |
| filingDate | 2010-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaa2c897c8a636dbc4361a69c7788285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b711fc5e0465e03ef2794ef8b7cf366f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ceb7689c3d14ceb11c5ce406e7a4b39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4173f36d45c1c70603495f857b57a9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f47aa5644e0bbef016ea62866a714e14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dd35e181f0efb66952b49bb7b31d43a |
| publicationDate | 2014-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2442179-T3 |
| titleOfInvention | Heteroaromatic derivatives of aryl triazoles as PDE10A enzyme inhibitors |
| abstract | A compound having structure I in which HET-1 is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms: in which Y can be N or CH, Z can be N or C, and in the that HET-1 may be optionally substituted with up to 3 individually selected R2-R4 substituents of hydrogen, C1-C6 alkyl; halogen; cyano; halo-C1-C6 alkyl; C1-C6 aryl, alkoxy and hydroxyalkyl, and in which * denotes the point of attachment, Q is a phenyl, optionally substituted with one to five substituents, a 5 or 6 membered monocyclic heteroaromatic group containing 1 or 2 heteroatoms -L -is a binding group selected from -S-CH2-, -CH2-S-, -CH2-CH2-, -CH> = CH-, and C≡CR1 is selected from H; C1-C6 alkyl; C 1 -C 6 alkyl (C 3 -C 8) cycloalkyl; C1-C6 hydroxyalkyl; CH2CN; CH2C (O) NH2; C1-C6 arylalkyl and C1-C6-heterocycloalkyl alkyl, with the proviso that the compound is not 1H-benzimidazole, 2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) uncle] methyl] -; 1Hbenzimidazole, 2 - [[[[3- (2-pyrazinyl) -1H-1,2,4-triazol-5-yl] methyl] thio] -; 1H-benzimidazole, 2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) methyl] thio] -; 1H-benzimidazole, 1-ethyl-5- (1-piperidinylsulfonyl) -2 - [[[3- (2-thienyl) -1H-1,2,4-triazol-5-yl] thio] methyl] -; 1Hbenzimidazole, 6-methyl-2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) thio] methyl] -; 1H-benzimidazole, 2 - [[[3- (3-pyridinyl) -1H-1,2,4-triazol-5-yl] methyl] thio] -; imidazo [1,2-a] pyridine, 8-methyl-2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) thio] methyl] -; imidazo [1,2-a] pyridine, 6-chloro-2 - [[[3- (2-thienyl) -1H-1,2,4-triazol-5-yl] thio] methyl] -; 1H-benzimidazole, 2 - [[[3- (4-pyridinyl) -1H-1,2,4-triazol-5-yl] methyl] thio] -; imidazo [1,2-a] pyridine, 6-methyl-2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) thio] methyl] -; 1H-benzimidazole, 2 - [[[3- (2-pyridinyl) -1H-1,2,4-triazol-5-yl] methyl] thio] -; imidazo [1,2-a] pyridine, 6-chloro-2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) thio] methyl] -; 3H-imidazo [4,5-b] pyridine, 2 - [[(3-phenyl-1H-1,2,4-triazol-5-yl) thio] methyl] -; or 1H-benzimidazole, 2 - [[[3- (2-furanyl) -1H-1,2,4-triazol-5-yl] methyl] thio] -; and its pharmaceutically acceptable tautomers and salts, and its polymorphic forms, with the proviso that when the binding group (L) is -CH2-S-, then HET-1 is neither imidazo [1,2-a] pyridine nor imidazo [1,2-a] pyrimidine. |
| priorityDate | 2009-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 777.